Influence of chelating agents on the toxicity, distribution and excretion of vanadium in mice

Journal of Applied Toxicology : JAT
J L DomingoJ Corbella

Abstract

The effects of the chelating agents Na2Ca-ethylendiaminetetraacetate (EDTA), Na3Ca-diethylentriaminepentaacetate (DTPA), L-cysteine, 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron) and deferoxamine mesylate and the reducing agent ascorbic acid on the toxicity, excretion and distribution of i.p. injected vanadium were studied in male Swiss mice. Chelating and reducing agents were administered intraperitoneally at doses equal to one-fourth of their respective LD50. To determine the effects of the various chelators on the mortality of vanadium, various doses of NaVO3 (0.30-1.20 mmol kg-1 i.p.) were given, followed immediately by one of the chelating or reducing agents. Survival was recorded at the end of 14 days. Significant increases in survival were noted with ascorbic acid, Tiron and deferoxamine, with ascorbic acid being the most effective. Deferoxamine and Tiron were the most effective in increasing the excretion of vanadium and reducing the concentration of vanadium found in various tissues. However, ascorbic acid appears to be the most effective agent in the prevention of vanadium intoxication.

References

Dec 1, 1985·Journal of Applied Toxicology : JAT·J L DomingoJ Corbella
Nov 1, 1984·Toxicology Letters·J M Llobet, J L Domingo
Jan 1, 1983·Toxicology·M HeideG F Fuhrmann
Oct 1, 1983·Journal of Toxicology and Environmental Health·M M Jones, M A Basinger
Oct 1, 1982·Journal of Toxicology and Environmental Health·C I WeiL D Hansen
Feb 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·W G MITCHELL, E P FLOYD

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Citations

Jul 1, 1989·Archives of Environmental Contamination and Toxicology·A OrtegaJ Corbella
May 15, 1989·Archives of Biochemistry and Biophysics·R J KellerL H Piette
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
Jun 7, 2002·Critical Reviews in Oncology/hematology·Angelos M Evangelou
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Aug 16, 2000·Journal of Applied Toxicology : JAT·P SharmaS Shukla
Dec 1, 1988·Journal of Applied Toxicology : JAT·M GómezJ L Paternain
Jun 1, 1990·Journal of Applied Toxicology : JAT·J L PaternainJ Corbella
Aug 30, 2008·Chemistry & Biodiversity·Enrique J Baran
Sep 1, 1988·Archives of Biochemistry and Biophysics·R J KellerL H Piette

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