PMID: 39416Jun 1, 1979

Influence of chlormethiazole on cerebral blood flow and oxygen consumption in the rat, and its effect on the recovery of cortical energy metabolism after pronounced, incomplete ischaemia

Acta Anaesthesiologica Scandinavica
C Carlsson, S Rehncrona

Abstract

The influence of an anaesthetic dose of chlormethiazole (Hemineurin) on blood flow (CBF) and oxygen consumption (CMRO2) in the rat brain was investigated. In spontaneously breathing animals a dose of 160 mg . kg-1 of chlormethiazole, infused i.v., induced a state close to surgical anaesthesia. In paralyzed animals, the same dose decreased CBF and CMRO2 to about 60% of control, an effect similar to that observed after an anaesthetic dose of phenobarbitone. Neither a protective nor a detrimental effect of chlormethiazole could be demonstrated when the drug was given during reversible and pronounced, incomplete ischaemia, as evaluated from the postischaemic tissue concentrations of labile phosphates (PCr, ATP, ADP, AMP) and of lactate and pyruvate. It is concluded that protection in this situation (as earlier shown with phenobarbitone) must, at least partly, be related to other mechanisms than a depression of metabolism.

References

Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A Hossmann
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·A WauquierG H Clincke
Jan 1, 1985·Canadian Anaesthetists' Society Journal·P A CasthelyM A Ergin
Feb 24, 2010·Ecotoxicology·Narendra Nath Singh, Anil Kumar Srivastava
Sep 1, 1991·Bulletin of Environmental Contamination and Toxicology·M D Ferrando, E Andreu-Moliner
Mar 6, 2020·Phytotherapy Research : PTR·Qingxuan XieXiaofang Li

Citations

Jul 1, 1978·Stroke; a Journal of Cerebral Circulation·C H Nordström, B K Siesjö
Jan 1, 1977·Journal of Neurochemistry·D E Levy, T E Duffy
Jan 1, 1975·Acta Anaesthesiologica Scandinavica. Supplementum·L Nilsson, B K Siesjö
Jun 1, 1972·Journal of Medical Genetics·R B Lowry
Dec 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·L BorgströmU Pontén
Nov 1, 1973·Journal of Neurochemistry·U PonténB K Siesjö
Jun 20, 1974·Brain Research·B LjunggrenB K Siesjö
Jun 1, 1974·Acta Physiologica Scandinavica·K Norberg, B K Siesjö
Jan 1, 1966·Acta Psychiatrica Scandinavica. Supplementum·J Y Chareton
Nov 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·I A Rose
Jan 1, 1966·Acta Psychiatrica Scandinavica. Supplementum·C O Svedin
Oct 1, 1969·British Journal of Anaesthesia·J WilsonD B Scott

Related Concepts

Metabolic Process, Cellular
Ischemia
Cerebral Blood Flow Imaging
Behavior, Animal
Lactate
Energy Metabolism
Diastolic Blood Pressure
Pyruvate Measurement
Brain
Red Cell Mass Result

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