PMID: 7526477Nov 1, 1994Paper

Influence of chlorpromazine, bleomycin and WR-2721 singly or in combination on the formation of radiation-induced micronuclei in mice bone marrow

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
G C Jagetia

Abstract

Radiotherapy of tumors is often accompanied by inadvertant side effects on the normal tissues after completion of the treatment, which may later on result in the development of secondary neoplasia. Aim was to investigate the effect of combination of radiosensitizing agents in combination with a radioprotector on the frequency of micronuclei in mouse bone marrow and to find out whether the administration of combination of radiosensitizing agents in combination with a radioprotective drug before irradiation will offer any significant advantage over the drugs used singly. Female BALB/c mice were divided into 8 groups according to the treatment they received viz. 1. DDW (double distilled water), 2. chlorpromazine (CPZ) 10 mg/kg body-weight, 3. CPZ 15 mg/kg body-weight 4. bleomycin (BLM), 5. WR-2721, 6. CPZ (10 mg) + WR-2721, 7. CPZ (15 mg) + WR-2721, 8. BLM + WR-2721. After 30 min of drug/s administration the animals were exposed to either 0 or 4 Gy of 60Co g-radiation. The animals were killed at 24 h post-irradiation by cervical dislocation and the micronuclei were prepared according to the method described by Jagetia [17]. The administration of CPZ (10 or 15 mg) alone increased the frequency of micronuclei significantly when comp...Continue Reading

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