Influence of Choroidal Microvasculature Dropout on the Rate of Glaucomatous Progression: A Prospective Study.

Ophthalmology. Glaucoma
Eun Ji LeeTae-Woo Kim

Abstract

To determine the prognostic significance of choroidal microvasculature dropout (MvD) to predict the future rate of progressive retinal nerve fiber layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG). Prospective, longitudinal case series. This study enrolled 101 eyes of 101 patients with POAG who underwent OCT angiography (OCTA) imaging of the optic nerve head at baseline and were followed up for at least 2 years thereafter, during which RNFL thickness was measured by serial spectral-domain OCT. The peripapillary microvasculature was evaluated by examining en face OCTA images. Choroidal MvD was defined as a focal sectoral capillary dropout with no visible microvascular network in the choroidal layer. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements. Influence of the presence of an MvD on the rate of subsequent RNFL thinning. Microvasculature dropout was identified in 48 eyes (47.5%). The rate of global RNFL thinning was significantly faster in eyes with MvD than eyes without MvD (-1.6±0.8 vs. -1.2±0.9 μm/year, P = 0.018). Eyes with MvD in the inferior hemisphere (n = 41) showed a faster rate of inferior RNFL thinning than eyes without MvD (P = 0.036). Eyes...Continue Reading

Citations

Nov 2, 2020·American Journal of Ophthalmology·Eren EkiciRobert N Weinreb
Dec 15, 2020·Korean Journal of Ophthalmology : KJO·Jounghan KimTae-Woo Kim
Jun 11, 2021·Translational Vision Science & Technology·Ou TanDavid Huang

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