Abstract
We studied the effect of chronic treatment with kanamycin on the basement membrane (BM) anionic sites in the cochlea and endolymphatic sac using polyethyleneimine (PEI) as a cationic tracer. Albino guinea pigs weighing 250-300 g received kanamycin (400 mg/kg/day, i.m.) for 10 or 17 consecutive days. The number of BM anionic sites as derived from the PEI area was not affected in Reissner's membrane, spiral prominence, basilar membrane or endolymphatic sac, whereas it was significantly decreased in the stria vascularis and spiral limbus, being more marked in the guinea pigs treated for 17 days than in those treated for 10 days. The number of BM anionic sites in these regions did not recover until 6 weeks after kanamycin treatment. These findings suggest that chronically administered kanamycin may selectively and progressively affect the BM anionic sites in the stria vascularis and spiral limbus, resulting in disruption of a barrier function in the cochlea, and that severely impaired BM anionic sites in the cochlea may not recover.
References
May 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J W SchurerI Molenaar
Jan 1, 1979·Acta Oto-laryngologica·T Konishi
Aug 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J W SchurerI Molenaar
Jul 1, 1978·Acta Oto-laryngologica·M TachibanaH Morioka
Jul 1, 1978·Acta Oto-laryngologica·Y Toyoda, M Tachibana
Jan 1, 1991·Acta Oto-laryngologica. Supplementum·M SuzukiY Nomura
Sep 1, 1991·Journal of Neurocytology·M S BushG Allt
Feb 1, 1988·Kidney International·G C GroggelW A Border
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·H YamaneK Konishi
Jan 1, 1988·Archives of Oto-rhino-laryngology·M TakumidaH Rask-Andersen
Jan 1, 1988·Archives of Oto-rhino-laryngology·K TomodaT Kumazawa
Dec 1, 1986·The Journal of Pathology·P N FurnessR E Cotton
Mar 1, 1985·Acta Oto-laryngologica·B GratacapP Stoebner
Sep 1, 1973·Audiology : Official Organ of the International Society of Audiology·E Hawkins
Aug 1, 1967·Acta Oto-laryngologica·T KonishiG T Singleton
Jan 1, 1983·Archives of Oto-rhino-laryngology·H YamaneY Minowa
Mar 1, 1981·Acta Oto-laryngologica·Y NakaiT Tokimoto
Jan 1, 1981·Archives of Oto-rhino-laryngology·W FirbasW Wicke
Jan 1, 1980·Acta Oto-laryngologica·J Santos-Sacchi, W F Marovitz
Jun 15, 1994·Hearing Research·K ToriharaT Morimitsu
Mar 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K ToriharaT Suganuma
Feb 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A W VorbrodtA S Lossinsky
Nov 1, 1995·Acta Oto-laryngologica·M SuzukiY Nomura
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M Suzuki, K Kaga
Citations
Mar 4, 2009·Journal of the Association for Research in Otolaryngology : JARO·Qi Wang, Peter S Steyger
Jul 27, 2001·Hearing Research·V Tsuprun, P Santi
Apr 13, 2002·Hearing Research·Mitsuya SuzukiKimitaka Kaga
Mar 21, 1998·Hearing Research·M SuzukiK Kaga
Apr 6, 1999·Hearing Research·M Suzuki, K Kaga
Jan 31, 1998·The Laryngoscope·M SuzukiK Kaga
Feb 6, 2015·Molecular Medicine Reports·Han ZhouXia Gao
Mar 6, 2010·Brain Research·W J KongX Huang
Nov 4, 2015·Neuroscience·U-R HeinrichK Helling
Nov 18, 2005·Neuroscience Letters·Tatsuya YamasobaMitsuya Suzuki
Feb 9, 2012·The Annals of Otology, Rhinology, and Laryngology·Mitsuya SuzukiTatsuya Yamasoba
Mar 28, 2001·The Annals of Otology, Rhinology, and Laryngology·M Suzuki, K Kaga
May 7, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Steven H HefeneiderDennis R Trune
Jan 23, 2021·Pharmaceutics·Rebekah Omarkhail Elliott, Mei He