Influence of chronic liver disease on coronary atherosclerosis vulnerability features

International Journal of Cardiology
Roberto OtsuboJosé Antonio Franchini Ramires

Abstract

A lower incidence of acute myocardial infarction was reported in patients with chronic liver disease. To analyze the impact of chronic liver disease on characteristics associated with vulnerability of human coronary artery atherosclerotic plaques. One hundred fourteen hearts were collected from 3 groups of individuals: A--38 chronic liver disease patients who died while on the waiting list for liver transplantation; B--38 individuals who died of natural causes; and C--38 individuals who died of accidental causes. The most obstructed portion of the initial 2-cm segment of coronary arteries was histologically evaluated regarding to plaque area, luminal area, inflammation, percentage of fat, and total vessel area. The mean age (years) and male frequency in groups A, B and C were, respectively, 52+/-9 and 79%; 52+/-11 and 71%; and 54+/-18 and 89%. The mean area of the plaque and the incidence of severe plaque inflammation in group A were significantly lower (4.2+/-3.2; 13.2%) than those in the other two groups (6.6+/-4.3; 84.2%, and 6.3+/-4.4; 52.6%) p<0.01. The cross-sectional vessel measures were not statistically different regarding to vessel area (10.5+/-4.6; 12.1+/-4.6; 13.0+/-4.4) p=0.08, luminal obstruction (45%+/-15%; 60%+/...Continue Reading

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Citations

Oct 30, 2008·Journal of Digestive Diseases·Norberto C Chavez-TapiaMisael Uribe
May 5, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javed EhtishamMartial Hamon
Apr 7, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ashraf Abd El-Khalik BarakatMervat Eldamarawy
Mar 13, 2008·Journal of Leukocyte Biology·Moreshwar S DesaiC W Smith

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