PMID: 9437228Jan 23, 1998Paper

Influence of chronic naltrexone treatment on growth hormone secretion in normal subjects

European Journal of Endocrinology
P VillaA Lanzone

Abstract

To verify if a chronic opioid blockade could affect the GH/IGF-I axis. We have investigated the effects of naltrexone (NTX) treatment on GH response to GHRH in normal women. GHRH test (50 micrograms i.v.) performed in seven normal female volunteers (age 25-38 years, with a body mass index ranging from 19.8 to 23.1 kg/m2) before and after 4-weeks NTX treatment (50 mg p.o. daily). Basal GH, IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3) plasma levels and the IGF-I/IGFBP-3 molar ratio remained unaffected by NTX. NTX significantly reduced the GH peak values (15.52 +/- 3.59 vs 4.78 +/- 0.49 micrograms/l; P < 0.01), and GH area under curve (918.93 +/- 253.96 vs 401.09 +/- 79.63 micrograms/l; P < 0.01). This finding suggests that the long-term opioid receptor blockade has an inhibitory role on GHRH-induced GH secretion. A central influence on neurotransmitter control of GH might be hypothesised. The inhibition of stimulated GH release, without interference with the basal level, could indicate an enhanced somatostatin secretion and/or activity. Opioids could be involved only in the regulation of GH dynamics and not in basal secretion. Nevertheless, a direct involvement of opioids at the pituitary level, which could be mo...Continue Reading

Citations

Nov 12, 2009·Endocrine Reviews·Cassidy VuongTheodore C Friedman
Dec 30, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Susan P DemarestRobert A Adler

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