Influence of clinical trial participation on subsequent antithrombin use.

Clinical Cardiology
Bimal R ShahMatthew T Roe

Abstract

Results from the Superior Yield of the New Strategy of Enoxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial showed that the low-molecular-weight heparin (LMWH) enoxaparin was non-inferior compared with unfractionated heparin (UFH) in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) managed invasively. We explored the influence of SYNERGY trial site participation on subsequent patterns of heparin use for NSTE-ACS patients treated in routine practice. We examined temporal patterns of LMWH use compared with UFH use among 122 764 patients with NSTE-ACS enrolled in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE) quality improvement initiative between January 1, 2002 and June 30, 2006, to determine whether site participation in SYNERGY influenced the type of heparin used before and after publication of the SYNERGY results in July 2004. A total of 118 out of 388 (30%) U.S. hospitals participating in CRUSADE simultaneously participated in SYNERGY. SYNERGY sites in the CRUSADE registry were more likely to have a teaching affiliation and have more hospital beds than non-SYNERGY centers in ...Continue Reading

References

Feb 15, 2001·Archives of Internal Medicine·C A JackeviciusJ V Tu
Nov 5, 2002·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·James W HoekstraW Brian Gibler
Dec 12, 2002·Journal of the American College of Cardiology·Robert M CaliffUNKNOWN American Heart Association
Jan 23, 2003·Circulation·Shaun G GoodmanUNKNOWN Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial Investigators
May 18, 2004·Journal of the American College of Cardiology·Sumit R MajumdarCurt D Furberg

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Citations

Oct 3, 2013·Clinical Trials : Journal of the Society for Clinical Trials·Rogier J N T M LitjensBen Willem J Mol

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