PMID: 38808Jan 1, 1978

Influence of clozapine on neuroleptigenic extrapyramidal motor disturbances (author's transl)

K J Zander, E Rüther


1. Human neuroleptogenic EPMS-disturbances are reversed by clozapine in animal experiments and in clinical use. This is consistent with the central anticholinergic efficacy of clozapine. 2. Clozapine seems to be a favourable concomitant medication when high dosage therapy of neuroleptics is applied--or at the incidence of dyskinesia.

Related Concepts

Antipsychotic Effect
Dyskinetic Syndrome
Lenticulostriate Disorders
Antipsychotic Agents
Anticholinergic [EPC]
Dyskinesia, Medication-Induced
Motor Disturbances
Parkinson Disease
Clinical Trials

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