Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts

ACS Omega
Emma M McCarthyLiam M Grover

Abstract

Metals on metal implants have long been used in arthroplasties because of their robustness and low dislocation rate. Several relatively low-corrosion metals have been used in arthroplasty, including 316L stainless steel, titanium, and cobalt-chromium-molybdenum alloy. Debris from these implants, however, has been found to cause inflammatory responses leading to unexpected failure rates approaching 10% 7 years surgery. Safety assessment of these materials traditionally relies on the use of simple two-dimensional assays, where cells are grown on the surface of the material over a relatively short time frame. It is now well-known that the composition and stiffness of the extracellular matrix (ECM) have a critical effect on cell function. In this work, we have evaluated how cobalt ions influence the assembly of type I collagen, the principle component of the ECM in bone. We found that cobalt had a significant effect on collagen matrix formation, and its presence results in local variations in collagen density. This increase in heterogeneity causes an increase in localized mechanical properties but a decrease in the bulk stiffness of the material. Moreover, when collagen matrices contained cobalt ions, there was a significant change...Continue Reading

References

Feb 1, 1975·Biopolymers·B G Frushour, J L Koenig
Oct 1, 1980·Biomaterials·H S Dobbs, M J Minski
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·D R HaynesD W Howie
Sep 15, 1995·Structure·J BellaH M Berman
Mar 5, 1998·The Journal of Bone and Joint Surgery. American Volume·J J JacobsR M Urban
Mar 6, 1999·The Journal of Bone and Joint Surgery. British Volume·H P SieberP Köttig
Jul 30, 2002·Acta Orthopaedica Scandinavica·Lucas AnissianElisabet Bucht
Jan 7, 2005·The Journal of Bone and Joint Surgery. American Volume·A P DaviesC P Case
Feb 21, 2006·Cell Biology International·Gary D Fullerton, Maxwell R Amurao
Jun 7, 2007·Journal of Cell Science·Karl E KadlerRaymond P Boot-Handford
Dec 8, 2009·Science·Richard O Hynes
Dec 10, 2009·Acta Orthopaedica·Gayana MahendraNick Athanasou
Dec 3, 2010·Journal of Cell Science·Christian FrantzValerie M Weaver
Mar 19, 2011·Toxicology·Klaudia Jomova, Marian Valko
Jul 20, 2011·The Journal of Bone and Joint Surgery. British Volume·D J LangtonA V F Nargol
Oct 3, 2012·Biotechnology Journal·Blake EricksonMark M Banaszak Holl
Jul 16, 2013·Current Opinion in Genetics & Development·William P Daley, Kenneth M Yamada
Jul 31, 2013·Clinical Orthopaedics and Related Research·Danyal H NawabiDouglas E Padgett
Aug 7, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley K MatthiesAlister J Hart
Jan 11, 2014·Lasers in Medical Science·José Luis González-SolísPascual Palomares-Anda
Jan 31, 2014·ACS Applied Materials & Interfaces·Alexander HoppeAldo R Boccaccini
Nov 19, 2014·World Journal of Orthopedics·Christoph H LohmannGottfried H Buchhorn
Nov 22, 2014·Nature Reviews. Molecular Cell Biology·Caroline BonnansZena Werb
Dec 4, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kathleen SchröckMichaela Schulz-Siegmund
May 2, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Karan M ShahAlison Gartland
May 15, 2015·Orthopedics·Phonthakorn PanichkulC Anderson Engh
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Alexander HoppeAldo R Boccaccini
Dec 16, 2016·Journal of Biomedical Materials Research. Part a·Jukka PajarinenStuart B Goodman
Feb 6, 2017·Frontiers in Endocrinology·Nadim J Hallab, Joshua J Jacobs
Jun 24, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M KochHollis G Potter

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Citations

Jul 10, 2020·Chemical Society Reviews·Maryam RahmatiHåvard J Haugen
May 15, 2020·Biological Trace Element Research·Ivelin VladovYordanka Gluhcheva
Oct 27, 2020·Advanced Science·Janosch SchoonSven Geissler
Nov 7, 2020·ACS Applied Materials & Interfaces·Seongsu EomDong Sung Kim

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Methods Mentioned

BETA
reflectance microscopy
AFM
X-ray
differential scanning calorimetry
rheology
force measurements
PCA

Software Mentioned

Carpick
MATLAB
Prism
Excel

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