PMID: 29782746Jan 1, 2016Paper

INFLUENCE OF COMBINED PHARMACOLOGICAL AND HYPOXIC PRECONDITIONING ON ANIMAL SURVIVAL AND FUNCTIONAL ACTIVITY OF CNS DURING MODEL CEREBRAL ISCHEMIA

Eksperimental'naia i klinicheskaia farmakologiia
O S LevchenkovaN S Ponamareva

Abstract

The combined action of amthizole administration and hypoxia conditions on the survival of rats and the functional state of the central nervous system has been studied on a model of bilateral common carotid artery occlusion. It is established that this combined preconditioning produces cerebroprotective action, increases animal survival after surgery (estimated 72 h upon the onset of ischemia) by 38% (p = 0.029) in early and by 29% (p = 0.078) in late period of the ischemia modeling, reduces neurological deficiency by 55% (p = 0.006) in early and by 43 % (p = 0.028) in late period of the ischemia modeling, and decreases severity of behavioral changes in rats caused by cerebral ischemia in both periods of ischemia modeling.

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