PMID: 9422034Dec 1, 1995Paper

Influence of compensated radioiodine therapy on thyroid volume and incidence of hypothyroidism in Graves' disease

Journal of Internal Medicine
B NygaardJ M Hansen

Abstract

To investigate the long-term effect of radioactive iodine (131I) on thyroid function and size in patients with Graves' disease. Out-patient clinic in Herlev Hospital. One hundred and seventeen consecutive patients (104 women) with Graves' disease selected for 131I treatment and followed for a minimum of 12 months (range 1-10 years, median 5 years). 131I dose was calculated based on thyroid volume and 24-h 131I uptake. Standard thyroid function variables and ultrasonically determined thyroid volume before treatment as well as 0.75, 1.5, 3, 6 and 12 months after treatment, and then once a year were investigated. Seventy-eight patients were cured by one 131I dose and 30 by two doses, while the remaining nine patients received additional doses (range one to five doses, median one dose). Within one year, 25% developed hypothyroidism, and hereafter, hypothyroidism developed at a constant rate of 3% per year independent of antithyroid pretreatment. The cumulative 10-year risk of hypothyroidism was 60%. Initial median thyroid volume was 33 mL (range 9-106 mL). At 12 months after the last 131I dose, median thyroid volume was reduced to 14 mL (range 6-36 mL) (P < 0.00001). The median reduction being 58% (range 0-80%), hereafter no furthe...Continue Reading

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Citations

Jun 16, 2004·Annals of Nuclear Medicine·Tamotsu KitaNorihisa Tonami
Jul 23, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Steen Joop BonnemaLaszlo Hegedüs
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Laszlo HegedüsThomas H Brix
Mar 31, 2009·Endocrinology and Metabolism Clinics of North America·Laszlo Hegedüs
Dec 24, 2010·European Journal of Clinical Investigation·Steen J BonnemaLaszlo Hegedüs
Jan 7, 2010·Clinical Endocrinology·Laszlo Hegedüs
Sep 1, 1995·Clinical Endocrinology·A E JarløvJ M Hansen
Jun 12, 1999·Thyroid : Official Journal of the American Thyroid Association·B NygaardJ M Hansen
Feb 18, 2003·Endocrine Reviews·Laszlo HegedüsFinn N Bennedbaek
Apr 13, 1999·The Journal of Clinical Endocrinology and Metabolism·O SabriU Buell
Sep 26, 2001·BMC Nuclear Medicine·Suhail AR DoiKamal AS Al-Shoumer
Jun 24, 2020·Wiener medizinische Wochenschrift·Christina Tugendsam, Amir Kurtaran
Oct 4, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giuliano MarianiH William Strauss

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