Influence of complement on the chemiluminescent response of human leukocytes to immune complex.

Infection and Immunity
S LöfgrenJ Carlsson

Abstract

Vaccine bacteria of Francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees C for 30 min. The mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. The initial peak was induced by a soluble agent, formed during incubation. The formation of this agent involved the activation of complement component C5. The second peak of the chemiluminescent response was induced by the opsonized bacteria; this peak was augmented by complement component C3, whereas C5 had no influence.

References

Dec 1, 1976·The Journal of Clinical Investigation·V G HemmingH R Hill
Nov 1, 1975·The Journal of Clinical Investigation·I M GoldsteinG Weissmann
Jul 1, 1976·The Journal of Clinical Investigation·H Rosen, S J Klebanoff
Jul 1, 1977·Infection and Immunity·B R AndersenT F Lint
May 1, 1978·The Journal of Clinical Investigation·L HarvathB R Andersen
May 17, 1979·The New England Journal of Medicine·L Harvath, B R Andersen
Jan 1, 1978·Journal of Immunological Methods·B R Andersen, A M Brendzel
Jan 1, 1978·Advances in Immunology·T E Hugli, H J Müller-Eberhard
Jan 1, 1979·Journal of Immunological Methods·C D AllredH R Hill
Jan 1, 1977·International Archives of Allergy and Applied Immunology·H R HillV G Hemming
Jan 1, 1978·The Journal of Experimental Medicine·G E HatchD B Menzel
Mar 1, 1978·Infection and Immunity·C D Allred, H R Hill
Oct 1, 1976·The Journal of Clinical Investigation·B D ChesonB M Babior
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E SchiffmannS M Wahl
Feb 1, 1973·Infection and Immunity·R L StjernholmJ A Harris
Jun 1, 1974·Infection and Immunity·L S WebbR B Johnston
Aug 1, 1965·The Journal of Experimental Medicine·U R NILSSON, H J MUELLER-EBERHARD

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Citations

Mar 1, 1984·Antimicrobial Agents and Chemotherapy·J GletteC O Solberg
Dec 10, 1989·Transfusion Science·W van OeverenM D Kazatchkine
Sep 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·J A Westman
Feb 1, 1984·Annals of the Rheumatic Diseases·R GaleP J Roberts-Thomson
Sep 1, 1983·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·R Mũller-PeddinghausW Schumacher

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