PMID: 3197741Jan 1, 1988Paper

Influence of continuous ambulatory peritoneal dialysis on serum alpha 1-acid glycoprotein concentration and drug binding

European Journal of Clinical Pharmacology
F M BelpaireN H Lameire

Abstract

The influence of continuous ambulatory peritoneal dialysis (CAPD) on the concentrations of alpha 1-acid glycoprotein in serum and dialysate and on the serum binding of oxprenolol, propranolol and phenytoin has been studied. Before starting CAPD treatment, the serum binding of oxprenolol and propranolol was higher and that of phenytoin lower than in healthy volunteers, and the serum alpha 1-AGP concentration was higher. During the first days to weeks after starting CAPD, the serum alpha 1-AGP concentration rose with a concomitant increase in the binding of oxprenolol and propranolol. Subsequently, the alpha 1-AGP level and the binding of oxprenolol and propranolol decreased to the values found before starting CAPD. The binding of phenytoin showed little change. The concentration of alpha 1-AGP in dialysate was 2 to 5% of that in serum.

References

Jan 1, 1976·European Journal of Clinical Pharmacology·D FremstadP K Lunde
Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Jul 29, 1971·The New England Journal of Medicine·M M ReidenbergF Sjöqvist
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Jan 1, 1982·European Journal of Clinical Pharmacology·F M BelpaireM Rosseneu
Mar 1, 1982·Clinical Pharmacology and Therapeutics·S H GrossmanP A Routledge
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J FeelyJ Crooks
Dec 1, 1980·Clinical Pharmacology and Therapeutics·J FeelyJ Crooks

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Citations

Apr 1, 1990·Journal of Clinical Pharmacology·F M Belpaire, M G Bogaert
Apr 28, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·N H FraeymanN H Lameire
Nov 11, 2018·Drug Metabolism and Personalized Therapy·Yuri TakahashiTakeshi Morimoto

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