PMID: 9647448Jul 1, 1998Paper

Influence of contrast media on the response of rat renal arteries to endothelin and nitric oxide: influence of contrast media

Investigative Radiology
M E MurphyS Li

Abstract

Contrast media (CM) such as diatrizoate meglumine (DTZ) or iohexol can cause renal vasoconstriction in vivo, and this may initiate CM-induced nephropathy. Endothelin-1 (ET-1), a vasoconstrictor, and nitric oxide, a vasodilator, are key modulators of renal circulation. We tested the hypothesis that CM enhances arterial responses to ET-1, or diminishes responses to nitric oxide. A video dimension analyzer continuously recorded changes in diameter of isolated, pressurized rat interlobar renal arteries (200-400 microm diameter) superfused with combinations of CM, ET-1, nitric oxide, and other vasoactive agents. Superfusion of arteries with 3.3% DTZ, but not with 3.3% iohexol, enhanced their sensitivity to ET-1 by approximately twofold, as assessed by shifts in concentration-response curves. Both DTZ and iohexol decreased the sensitivity of arteries to nitric oxide by approximately threefold. Neither DTZ nor iohexol affected arterial sensitivity to other vasoconstrictors (phenylephrine, potassium) or vasodilators (forskolin, diltiazem). Diatrizoate meglumine and iohexol may induce or augment renal vasoconstriction in part by causing selective alterations in arterial sensitivity to ET-1 and to nitric oxide.

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Citations

Jan 26, 2013·European Heart Journal·Darko MarkotaIvica Brizic
Dec 1, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shih-Ping HsuChiang-Ting Chien
Feb 26, 2011·Clinical and Experimental Pharmacology & Physiology·Mauricio M Sendeski
Apr 20, 2005·Journal of General Internal Medicine·Raymond LiuStephen Bent
Nov 18, 2004·AJR. American Journal of Roentgenology·Tadhg G Gleeson, Sudi Bulugahapitiya
Feb 7, 2003·The New England Journal of Medicine·Carl M Sandler
May 13, 2003·Expert Opinion on Pharmacotherapy·Edward P Mintz, Luis Gruberg
Jun 25, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Francisco Tortoledo
Jul 3, 2013·Journal of Cardiovascular Medicine·Ugo LimbrunoRaffaele De Caterina
Dec 10, 1999·Investigative Radiology·V M Runge
Jan 14, 2005·The International Journal of Artificial Organs·H M Oudemans-van Straaten

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