Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans

Acta Physiologica Scandinavica
S FreudenthalerC H Gleiter

Abstract

The present study was carried out to evaluate a model of a hypoxic stimulus of erythropoietin (EPO) production in humans and to investigate the role of free oxygen radicals in human EPO production. The study was conducted as an open, randomized, parallel, placebo-controlled trial. Thirty-six healthy male volunteers received a hypoxic treatment (13% O(2)) with a respiration mask for 6 h. During the period of hypoxia, the volunteers received as a short-term treatment either 1200 mg thioctic acid, or N-acetylcysteine 600 mg or placebo (0.9% sodium chloride). The EPO concentration in plasma increased up to 290% of the baseline level in all three groups. No statistically significant differences of AUC(EPO(0-48 h)) could be demonstrated between the groups. The malondialdehyde (MDA) concentration in plasma increased significantly (P < 0.001) 2 h after termination of hypoxia (mean 129.8 +/- 6.8% of the baseline) in all three groups. Taken together, our in-vivo results do not support a gross modulatory effect of a short-term treatment with radical scavenging agents on EPO-production during or after hypoxia in humans, as derived from the detected changes of MDA-concentrations in peripheral plasma.

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Citations

Jun 17, 2005·Journal of Neural Transmission·W JordanS Bleich
Apr 1, 2010·Journal of Physiology and Biochemistry·A Zembron-LacnyK Szyszka
May 8, 2004·Experimental Gerontology·Maria Heloisa Massola ShimizuAntonio Carlos Seguro
Jun 10, 2009·The American Journal of Chinese Medicine·Shiqing LinXuanhong Zhang
Feb 28, 2008·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·E GuneliN Uysal
Oct 14, 2009·Journal of Physiological Anthropology·Daisuke AndoKatsuhiro Koyama
Dec 6, 2008·World Journal of Gastroenterology : WJG·Si-Qi XuLiu-Yi Dong
Aug 20, 2011·Pakistan Journal of Biological Sciences : PJBS·P AnandT Balasubramanian
Mar 12, 2011·European Journal of Applied Physiology·Mona MomeniGiuseppe Liistro
Sep 13, 2003·British Journal of Clinical Pharmacology·S FreudenthalerC H Gleiter
Dec 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mehmet KanterMustafa Erboga
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M Cudi TuncerH Buyukbayram

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