Influence of corticostriatal δ-opioid receptors on abnormal involuntary movements induced by L-DOPA in hemiparkinsonian rats

Experimental Neurology
Fabrice BilletN Dourmap

Abstract

Chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment of Parkinson's disease induces in time numerous side effects, such as abnormal involuntary movements called L-DOPA-induced dyskinesias (LIDs). An involvement of glutamate transmission, dopamine transmission and opioid transmission in striatal output pathways has been hypothesized for the induction of LIDs. Interestingly, our previous experiments indicated that some striatal δ-opioid receptors are located on terminals of glutamatergic corticostriatal neurons and that stimulation of these receptors modulates the release of glutamate and dopamine. The present study was performed to test the involvement of δ-opioid receptors, and more precisely of those located on corticostriatal neurons, in abnormal involuntary movements induced by L-DOPA in hemiparkinsonian rats. The effects of a selective agonist, [D-Pen(2), D-Pen(5)]-enkephalin (DPDPE) and a selective antagonist (naltrindole) of δ-opioid receptors on LIDs were investigated in animals submitted or not to a corticostriatal deafferentation. Our results indicate that DPDPE and naltrindole respectively enhanced and reduced LIDs in animals in which the ipsilateral cortex was preserved intact. However, the lesion of the ipsilater...Continue Reading

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Oct 26, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Weidong LeJoseph Jankovic
Jun 15, 2013·Pharmacology & Therapeutics·Paul Chu Sin Chung, Brigitte L Kieffer
Jan 30, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F NiccoliniM Politis
Aug 5, 2018·CNS Neuroscience & Therapeutics·Jin-Zhong HuangYing Xia
Apr 12, 2019·Biomolecules·Fabio Del BelloWilma Quaglia
Jun 18, 2020·Life·Carla FerreiraAlexandre Quintas

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