Influence of CT acquisition and reconstruction parameters on radiomic feature reproducibility

Journal of Medical Imaging
Abhishek MidyaAmber L Simpson

Abstract

High-dimensional imaging features extracted from diagnostic imaging, called radiomics, are increasingly reported for diagnosis, prognosis, and response to therapy. Establishing the sensitivity of radiomic features to variation in scan protocols is necessary because acquisition and reconstruction parameters can vary widely across and within institutions. Our objective was to assess the reproducibility of radiomic features derived from computed tomography (CT) images by varying tube current (mA), noise index, and reconstruction [adaptive statistical iterative reconstruction (ASiR)], parameters increasingly varied by institutions seeking to reduce radiation dose in their patients. We extracted radiomic features from CT images of a uniform water phantom, anthropomorphic phantom, and a human scan. Scans were acquired from the phantoms with six tube currents (50, 100, 200, 300, 400, and 500 mA) and five noise index levels (12, 14, 16, 18, and 20), respectively. Scans of the phantoms and patient were reconstructed from 0% ASiR (i.e., filtered back projection) to 100% ASiR in increments of 10%. Two hundred and forty-eight well-known radiomic features were extracted from all scans. The concordance correlation coefficient was used to ass...Continue Reading

References

Feb 16, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·X Tang
Jul 4, 2008·IEEE Transactions on Bio-medical Engineering·Omar S Al-Kadi, D Watson
Nov 26, 2010·Investigative Radiology·Balaji GaneshanKenneth Miles
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Aug 18, 2012·Magnetic Resonance Imaging·Virendra KumarRobert J Gillies
Apr 29, 2014·Translational Oncology·Yoganand BalagurunathanRobert J Gillies
Apr 29, 2014·Translational Oncology·Binsheng ZhaoLin Lu
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Dec 30, 2014·Journal of the American College of Surgeons·Amber L SimpsonRichard K G Do
Jul 24, 2015·Radiology·Lucas L GeyerCarlo N De Cecco
Mar 25, 2016·Scientific Reports·Binsheng ZhaoLawrence H Schwartz
Apr 19, 2016·United European Gastroenterology Journal·Sheng-Xiang RaoRegina Gh Beets-Tan

❮ Previous
Next ❯

Citations

Jan 11, 2019·Medical Physics·Petros KalendralisLeonard Wee
Oct 3, 2018·Contrast Media & Molecular Imaging·Francesca GallivanoneIsabella Castiglioni
Feb 9, 2020·European Radiology Experimental·Roberto GattaAntoine Leimgruber
Jan 27, 2019·Scientific Reports·Alex ZwanenburgSteffen Löck
Dec 13, 2019·BioMed Research International·Rafał ObuchowiczMichał Strzelecki
Jun 21, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Isabella Fornacon-WoodGareth J Price
Mar 20, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Sandra DoriaAdriana Taddeucci
Mar 16, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Matteo TamponiMaurizio Conti
Oct 11, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aria NazeriRichard L Wahl
Feb 4, 2021·Aging and Disease·Qian ChenYunjun Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.