Influence of curvature dynamics on pulsatile coronary artery flow in a realistic bifurcation model

Journal of Biomechanics
Martin ProsiMorton H Friedman

Abstract

The coronary arteries undergo large dynamic variations during each cardiac cycle due to their position on the beating heart. The local artery curvature varies significantly. In this study the influence of dynamic curvature on coronary artery hemodynamics is analyzed numerically. A realistic model of the bifurcation of the left anterior descending coronary artery and its first diagonal branch is curved by attaching it to the surface of a sphere with time-varying radius based on experimental dynamic curvature data. The description of the blood flow uses the time-dependent, three-dimensional, incompressible Navier-Stokes equations for Newtonian fluids, where the influence of the time-dependent flow domain is taken into account employing the Arbitrary Lagrangian-Eulerian technique. The inlet velocity profiles used in the computer simulation are physiologically realistic. The results show that the skewing of the axial velocity profiles near the branching site is mainly determined by the vessel branch; the bifurcating flow generally dominates the effect of curvature. The influence of curvature increases downstream of the branch. During systole, when curvature is greatest and high curvature variations appear, their effect on the flow ...Continue Reading

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Citations

Feb 26, 2008·Biomechanics and Modeling in Mechanobiology·J Scott VanEppsDavid A Vorp
Oct 20, 2006·Annals of Biomedical Engineering·Maheshwaran K KolandavelPeter G Walker
Mar 31, 2010·Annals of Biomedical Engineering·Ryan L Spilker, Charles A Taylor
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Jul 17, 2009·Journal of Biomechanical Engineering·Lucy M O'KeeffeTim McGloughlin
Dec 31, 2011·Journal of Biomechanical Engineering·Stefano MorlacchiFrancesco Migliavacca
Jul 1, 2012·Journal of Biomechanical Engineering·N K C Selvarasu, Danesh K Tafti
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Aug 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ji ZhangMorton H Friedman
Oct 5, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Saami K YazdaniRenu Virmani
Mar 13, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Claudio ChiastraMauro Malvè
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Apr 27, 2017·International Journal for Numerical Methods in Biomedical Engineering·Hossein Ali PakravanBahar Firoozabadi
Jul 22, 2018·Journal of Biomechanical Engineering·Daphne MezaWei Yin

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