Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking

Pharmacogenetics and Genomics
Maria DobrinasChin B Eap


Cytochrome P4501A2 (CYP1A2) presents a high interindividual variability in its activity and also in its inducibility by smoking. Cytochrome P450 oxidoreductase (POR) is an electron transfer protein that catalyzes the activity of several cytochromes P450. We aimed to study the influence of POR genetic polymorphisms on CYP1A2 activity while smoking and after smoking cessation, as well as on CYP1A2 inducibility. CYP1A2 activity was determined by the paraxanthine/caffeine ratio in 184 smokers and in 113 of these smokers who were abstinent during a 4-week period. Participants were genotyped for POR rs17148944G>A, rs10239977C>T, rs3815455C>T, rs2286823G>A, rs2302429G>A, and rs1057868C>T (POR*28) polymorphisms. While smoking, none of the tested POR polymorphisms showed a significant influence on CYP1A2 activity. After smoking cessation, significantly higher CYP1A2 activity was found in POR rs2302429A carriers (P=0.038) and in carriers of rs17148944G-rs10239977C-rs3815455T-rs2286823G-rs2302429A-rs1057868T haplotype (P=0.038), whereas carriers of POR rs2286823A (P=0.031) and of the rs17148944G-rs10239977C-rs3815455C-rs2286823A-rs2302429G-rs1057868C haplotype (P=0.031) had decreased CYP1A2 activity. In the complete regression model, only...Continue Reading


Oct 1, 1995·Clinical Pharmacology and Therapeutics·O SpigsetR Dahlqvist
May 24, 2001·The Journal of Biological Chemistry·P A HubbardJ J Kim
Feb 5, 2003·The Journal of Biological Chemistry·Colin J HendersonC Roland Wolf
Mar 18, 2003·Journal of Clinical Psychopharmacology·Juan Antonio CarrilloJulio Benítez
Jun 23, 2004·Journal of Clinical Psychopharmacology·Chin B EapFranck Broly
Oct 26, 2005·Biochemical and Biophysical Research Communications·Bettie Sue Siler Masters
Mar 21, 2007·European Journal of Clinical Pharmacology·Roza GhotbiLeif Bertilsson
Sep 8, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lisa A Kroon
Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ningwu HuangWalter L Miller
Jun 14, 2008·Pharmacogenetics and Genomics·Vishal AgrawalWalter L Miller
Oct 14, 2010·Pharmacogenetics and Genomics·Duanpen SandeeWalter L Miller
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Dec 18, 2010·Endocrine Development·Christa E Flück, Amit V Pandey
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Jan 29, 2013·Pharmacology & Therapeutics·Amit V Pandey, Christa E Flück
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May 7, 2013·Expert Opinion on Drug Metabolism & Toxicology·Vidya PereraAndrew J McLachlan
Jul 17, 2012·Gynecologic Oncology·Lucy S HodgeTimothy S Tracy
Oct 11, 2012·Pharmacogenetics and Genomics·Lei HuLan Fan
Aug 5, 2014·Therapeutic Drug Monitoring·Fabian CzerwenskyWerner Steimer
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Related Concepts

CYP1A2 protein, human
Enzyme Induction
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