Influence of day of pregnancy on rat placental, uterine, and ovarian prostaglandin synthesis and metabolism.

Endocrinology
P CarminatiL J Lerner

Abstract

Synthesis and metabolism of prostaglandins in reproductive tissues of the gravid rat were studied from the time of post-implantation to just prior to parturition. Rat placental prostaglandin synthesis is low on day 8 of pregnancy, sharply increases on day 11, falls on day 14, and remains at a low level for the remainder of gestation. In the tissue PGE2 synthesis is 6 times greater than that of PGF2alpha on day 11. Prostaglandin metabolism in the placenta was high on day 11, low on days 8 and 14, and elevated on days 16, 18, and 21 of pregnancy. PGE1 metabolism was 8 times greater than that of PGF2alpha. Uterine prostaglandin synthesis was low until day 16, and then increased until the end of pregnancy. PGE2 synthesis was very low in this tissue in comparison to PGF2alpha synthesis. Prostaglandin metabolism in the uterus was relatively low until day 16 and then sharply increased for the remainder of gestation. This increase in metabolism was not directly proportional to uterine growth. PGE1 metabolism was 5 times higher than PGF2alpha metabolism in this organ. Ovarian prostaglandin synthesis was very low in comparison to that of the other reproductive organs. Prostaglandin metabolism in this tissue decreased from day 8 through d...Continue Reading

Citations

Apr 1, 1983·Prostaglandins·T GimenezD M Henricks
Jul 1, 1995·Prostaglandins·A JawerbaumM A de Gimeno
Oct 1, 1983·Prostaglandins, Leukotrienes, and Medicine·I MuchaS Bagdány
Jan 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K Tsuruta, N Mori
Apr 1, 1979·Prostaglandins and Medicine·B H Vickery
Jan 1, 1978·Prostaglandins·M J DuchesneA C de Paulet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.