PMID: 15235319Jul 6, 2004Paper

Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise

Medicine and Science in Sports and Exercise
Katrien KoppoAndrew M Jones

Abstract

To test the hypothesis that pharmacological activation of the pyruvate dehydrogenase enzyme complex (PDC) with dichloroacetate (DCA) would speed phase II pulmonary oxygen uptake ((.-)V(O2)) kinetics after the onset of subsequent moderate-intensity (40-45% ((.-)V(O2)) peak) cycle exercise. Seven healthy males (mean +/- SD age 25 +/- 4 yr, body mass 75.3 +/- 9.4 kg) performed four "square-wave" transitions from unloaded cycling to a work rate requiring 90% of the predetermined gas exchange threshold either with or without prior infusion of DCA (50 mg x kg body mass in 50 mL saline). Pulmonary ((.-)V(O2)) was measured breath-by-breath in all tests and ((.-)V(O2)) kinetics were determined from the averaged individual response to each condition using nonlinear regression techniques. The blood [lactate] measured immediately before the onset of exercise was significantly reduced in the DCA condition (C: 1.1 +/- 0.3 vs DCA: 0.6 +/- 0.3 mM; P < 0.01) consistent with successful activation of the PDC. However, DCA had no discernible effect on the rate at which ((.-)V(O2)) increased toward the steady state after the onset of exercise as reflected in the phase II time constant (C: 28.5 +/- 11.8 vs DCA: 29.4 +/- 14.9 s). The results suggest ...Continue Reading

References

Feb 1, 1992·Journal of Applied Physiology·D C PooleP D Wagner
Feb 1, 1990·Medicine and Science in Sports and Exercise·B J Whipp, S A Ward
Feb 1, 1996·The Journal of Clinical Investigation·J A TimmonsP L Greenhaff
Dec 1, 1995·Journal of Applied Physiology·S M PhillipsR L Hughson
Mar 1, 1996·Journal of Applied Physiology·B GrassiP D Wagner
Feb 14, 1998·The Journal of Clinical Investigation·J A TimmonsP L Greenhaff
May 13, 1999·Biochimica Et Biophysica Acta·G C Brown
Sep 25, 2001·Journal of Applied Physiology·R S RichardsonL R Frank
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Ingrid SavasiLawrence L Spriet
Aug 6, 2002·Respiratory Physiology & Neurobiology·Casey A KindigDavid C Poole
Oct 17, 2002·The Journal of Physiology·Paul A RobertsPaul L Greenhaff
Nov 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard A Howlett, Michael C Hogan
Feb 10, 2004·Medicine and Science in Sports and Exercise·Katrien KoppoAndrew M Jones

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Citations

May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nicolas J A Berger, Andrew M Jones
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Darren S DeLoreyJohn M Kowalchuk
Oct 23, 2004·The Journal of Physiology·James A TimmonsPaul L Greenhaff
Mar 23, 2011·Respiratory Physiology & Neurobiology·Simon MarwoodPeter Calverley
Jul 21, 2009·Respiratory Physiology & Neurobiology·Daryl P WilkersonAndrew M Jones
Feb 15, 2005·Experimental Physiology·Leonardo F FerreiraThomas J Barstow
Dec 8, 2004·Journal of Applied Physiology·Brendon J GurdJohn M Kowalchuk
Sep 24, 2005·Medicine and Science in Sports and Exercise·Andrew M Jones, David C Poole
Sep 24, 2005·Medicine and Science in Sports and Exercise·Brandon WalshMichael C Hogan
Jan 6, 2005·Medicine and Science in Sports and Exercise·James A Timmons
Oct 19, 2007·American Journal of Physiology. Cell Physiology·Brian GlancyWayne T Willis
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendon J GurdJohn M Kowalchuk

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