Influence of decompression sickness on vasocontraction of isolated rat vessels

Journal of Applied Physiology
Aleksandra MazurFrançois Guerrero

Abstract

Studies conducted in divers indicate that endothelium function is impaired following a dive even without decompression sickness (DCS). Our previous experiment conducted on rat isolated vessels showed no differences in endothelium-dependent vasodilation after a simulated dive even in the presence of DCS, while contractile response to phenylephrine was progressively impaired with increased decompression stress. This study aimed to further investigate the effect of DCS on vascular smooth muscle. Thirty two male Sprague-Dawley rats were submitted to the same hyperbaric protocol and classified according to the severity of DCS: no-DCS (without clinical symptoms), mild-DCS or severe-DCS (dead within one hour). A control group remained at atmospheric pressure. Isometric tension was measured in rings of abdominal aorta and mesenteric arteries. Single dose contraction was assessed with KCl solution. Dose-response curves were obtained with phenylephrine and endothelin-1. Phenylephrine-induced contraction was observed in the presence of antioxidant TEMPOL. Additionally plasma concentration of angiotensin II, angiotensin converting enzyme and TBARS were assessed. Response to phenylephrine was impaired only among mild-DCS in both vessels. Do...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H Esterbauer, K H Cheeseman
Jun 18, 2005·The Journal of Physiology·A O BrubakkZ Dujic
Feb 3, 2007·Medicinal Chemistry·Xiaoyan Zhou, Edward D Frohlich
Dec 11, 2007·Aviation, Space, and Environmental Medicine·Ante ObadZeljko Dujić
Mar 4, 2008·Aviation, Space, and Environmental Medicine·Tina Little, Bruce D Butler
Nov 13, 2008·European Journal of Applied Physiology·R V VinceL A Madden
Nov 26, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bea ZoerEduardo Villamor
Dec 8, 2009·Pflügers Archiv : European journal of physiology·Eric Thorin, David J Webb
Jan 29, 2010·Pflügers Archiv : European journal of physiology·Agostino VirdisStefano Taddei
Aug 20, 2010·Clinical Physiology and Functional Imaging·Ante ObadZeljko Dujic
Oct 23, 2010·Journal of Applied Physiology·Stephen R ThomTatyana N Milovanova
Jun 3, 2011·American Journal of Physiology. Cell Physiology·Peter SobolewskiDavid M Eckmann
Oct 4, 2011·European Journal of Applied Physiology·Jasna MarinovicZeljko Dujic
Mar 26, 2013·Advances in Colloid and Interface Science·Virginie PapadopoulouMeng-Xing Tang
Aug 21, 2013·European Journal of Applied Physiology·Kate LambrechtsFrançois Guerrero
Sep 28, 2013·Journal of Applied Physiology·Nicolas ValléeJean-Eric Blatteau
Oct 1, 2013·European Journal of Applied Physiology·Sigrid TheunissenCostantino Balestra
Jan 9, 2014·Physiological Reports·Kate LambrechtsFrancois Guerrero
Mar 1, 2014·Medicine and Science in Sports and Exercise·Dennis MaddenZeljko Dujic
Sep 3, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Aleksandra MazurFrancois Guerrero
Nov 8, 2014·Medicine and Science in Sports and Exercise·Qiong WangMichaël Theron
Dec 3, 2014·Computers in Biology and Medicine·Peter BuzzacottFrançois Guerrero

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Citations

Sep 13, 2016·Scientific Reports·Kun ZhangWeigang Xu
Jan 23, 2017·European Journal of Applied Physiology·Kate LambrechtsFrançois Guerrero
Jul 22, 2017·Medicine and Science in Sports and Exercise·Jacky LautridouFrançois Guerrero
Jul 24, 2020·Journal of Applied Physiology·Jacky LautridouFrançois Guerrero
Apr 8, 2017·Frontiers in Physiology·Kun ZhangWeigang Xu
Mar 17, 2018·Frontiers in Physiology·Aleksandra MazurFrançois Guerrero
Jun 27, 2019·Minerva anestesiologica·Costantino BalestraJacek Kot
Nov 7, 2019·European Journal of Applied Physiology·Dirk Mayer, Katja Bettina Ferenz

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