PMID: 11905553Mar 22, 2002Paper

Influence of deficient alpha1-anti-trypsin phenotypes on clinical characteristics and severity of asthma in adults

Respiratory Medicine
Marc MiravitllesR Vidal

Abstract

Severe alpha1-anti-trypsin (AAT) deficiency implies a high risk of pulmonary emphysema development. The possible relationship between partial deficiencies of this enzyme and bronchial asthma remains controversial. The objective of this study was to ascertain the distribution of AAT phenotypes in a non-selected asthmatic patient population. Across-sectional study on a sample of 111 patients with asthma was carried out. Demographic and clinical variables were collected with serum IgE concentrations, plasma eosinophil number and serum AAT concentrations determined, together with the Pi phenotype. Asthma was mild in 36 (32.4%) patients, moderate in 45 (40.5%) and severe in 30 (27%). No differences were observed in eosinophil count or serum IgE or AAT concentrations among patients with different degrees of severity. Twenty-two (19.8%) asthmatics with deficient phenotypes for AAT were identified, distributed equally in all severity stages of the disease. No significant differences were found in clinical and functional characteristics, or in asthma morbidity between PiMM and PiMS patients or the heterozygote group (PiMS and PiMZ). Eosinophil count and IgE concentrations did not differ significantly between asthmatics with normal pheno...Continue Reading

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Citations

Dec 12, 2012·Comparative and Functional Genomics·Manish KumarG L Sharma
Dec 21, 2006·Archivos de bronconeumología·Rafael VidalUNKNOWN Committee on the National Registry of Individuals with Alpha-1 Antitrypsin Deficiency
Sep 24, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M AielloA Chetta
Aug 13, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Aquiles A CamelierMarc Miravitlles
Nov 10, 2018·Clinical and Translational Allergy·I Suárez-LorenzoT Carrillo-Diaz
Dec 8, 2020·Current Opinion in Allergy and Clinical Immunology·Laura PiniUNKNOWN Asthma and Alpha1-Antitrypsin Research Group
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology

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