Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes

Human Psychopharmacology
Francesca FeliceAlberto Balbarini

Abstract

Circulating endothelial progenitor cells (EPCs) are related to endothelial function and progression of coronary artery disease. There is evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression. We investigated the relationships between the level of circulating EPCs and depression and anxiety in patients with acute coronary syndrome (ACS). Patients with ACS admitted to three Cardiology Intensive Care Units were evaluated by the SCID-I to determine the presence of lifetime and/or current mood and anxiety disorders according to DSM-IV criteria. The EPCs were defined as CD133(+) CD34(+) KDR(+) and evaluated by flow cytometry. All patients underwent standardized cardiological and psychopathological evaluations. Parametric and nonparametric statistical tests were performed where appropriate. Out of 111 ACS patients, 57 were found to have a DSM-IV lifetime or current mood or anxiety disorder at the time of the inclusion in the study. The ACS group with mood or anxiety disorders showed a significant decrease in circulating EPC number compared with ACS patients without affective disorders. In addition, EPC levels correlated negatively with severity of depression and anxiety at index ACS e...Continue Reading

References

Jul 13, 2001·The American Journal of Cardiology·S RajagopalanB Pitt
Oct 12, 2001·The American Journal of Cardiology·P Libby
Aug 15, 2002·Transplantation Proceedings·M Roy First
Oct 17, 2002·Heart·A J M BroadleyM P Frenneaux
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mihail HristovPeter C Weber
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Sep 23, 2003·European Heart Journal·Antonio Di ChiaraUNKNOWN BLIT Investigators
Jun 12, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Takahisa KondoToyoaki Murohara
May 20, 2009·Seminars in Thrombosis and Hemostasis·Giuseppe LippiMassimo Franchini
Oct 29, 2009·Heart·Nancy Frasure-Smith, François Lespérance
Dec 9, 2009·Harvard Review of Psychiatry·Laura K Kent, Peter A Shapiro
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Oct 17, 2013·Stroke; a Journal of Cerebral Circulation·Hiroto IshikawaCesar V Borlongan
Feb 26, 2014·Circulation·Judith H LichtmanUNKNOWN American Heart Association Statistics Committee of the Council on Epidemiology and Prevention and the Council on Cardiovascu
Apr 2, 2014·Journal of Cardiovascular Medicine·Rossella Di StefanoAlberto Balbarini

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Citations

Sep 28, 2016·Current Psychiatry Reports·Christopher M CelanoJeff C Huffman
Feb 11, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Jolly Mounir William LabibAhmed M Abdel-Tawab
Apr 14, 2020·Current Neuropharmacology·Mervin Chávez-CastilloJoselyn Rojas-Quintero
Aug 24, 2021·Frontiers in Cellular Neuroscience·Nana YangGuohua Lu

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