PMID: 6171616Jan 1, 1981Paper

Influence of descending bulbospinal monoamine neurons on axonal transport of acetylcholine and cholinergic enzymes

Journal of Neural Transmission
S BööjA Dahlström

Abstract

The influence of descending bulbospinal monoamine (MA) neurons on the intra-axonal transport of acetylcholine (ACh) and related enzymes (cholineacetyltransferase, CAT, and ACh-esterase, AChE) in rat sciatic nerve was studied in crush experiments following intracisternal injections of specific neurotoxins. The injection of 6-hydroxydopamine (6-OH-DA) and 5,6-dihydroxytryptamine (5,6-diOH-TA) (50 micrograms X 2) caused a degeneration of catecholamine (CA) and 5-hydroxytryptamine (5-HT) nerve terminals, respectively, and a combination of the two neurotoxins caused a loss of virtually all MA terminals in the lumbar spinal cord. The results of the neurotoxin injections were controlled by the Falck-Hillarp fluorescence method. The effect of neurotoxin treatment on the enzyme activities in the sciatic nerve was very small. The ACh levels of uncrushed nerves and in nerves proximal to a crush performed 12 hours before dissection decreased following either 6-OH-DA or 5,6-diOH-TA. However, the combination treatment with both 6-OH-DA and 5,6-diOH-TA had no influence on ACh accumulation and transport, as compared to the control group. In a previous study we have shown that mid-thoracic spinal cord transection increased AChE-transport while ...Continue Reading

References

Jan 1, 1975·Advances in Comparative Physiology and Biochemistry·J P Heslop
Feb 1, 1976·The Journal of Physiology·S Ochs
Aug 1, 1977·Journal of Neurochemistry·M A Bisby, V T Bulger
Jan 1, 1979·Annual Review of Neuroscience·J H Schwartz
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Jun 17, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Dahlström
Jan 1, 1973·Journal of Neurobiology·N R SaundersA B Dahlström
Jun 1, 1969·Journal of Neurochemistry·J Skangiel-KramskaL Lubińska
Jan 1, 1974·Journal of Neural Transmission·A B DahlströmN R Saunders
Sep 1, 1968·The Biochemical Journal·F Fonnum
Oct 1, 1959·The Journal of Comparative Neurology·L LUBINSKA
Mar 25, 1943·The Journal of Physiology·W Feldberg
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