Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria

International Journal of Dermatology
N CassanoGino A Vena

Abstract

Recent findings suggest the involvement of oxidative stress in the pathogenesis of chronic idiopathic urticaria (CIU). It has been demonstrated that desloratadine has an antioxidant activity in vitro. We evaluated the effects of desloratadine on markers of oxidative stress in patients with CIU. Blood samples were obtained from 10 patients with CIU before and after 4 weeks of treatment with desloratadine. Blood samples from 10 healthy volunteers were used as controls. In platelets from both patients and controls, radical oxygen species (ROS) production was measured using spectrofluorimetric detection of dichloro-fluorescein oxidation, and superoxide dismutase (SOD) activity was determined by means of the xanthine-xanthine oxidase system. Radical oxygen species concentrations and SOD activity were significantly elevated in patients with CIU at baseline as compared with control subjects. Treatment with desloratadine caused a relevant reduction of ROS levels and SOD activity (P<0.005). These preliminary results suggest that desloratadine exerts antioxidant effects also in vivo.

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Citations

Jul 12, 2013·Cutaneous and Ocular Toxicology·Göknur KalkanMehmet Sahin
Jul 24, 2015·International Forum of Allergy & Rhinology·Arzu TatarZekai Halici
Jan 23, 2016·Allergologia et immunopathologia·S SoltaniN Rezaei
Jan 18, 2011·Allergologia et immunopathologia·A SagdicA Aydin
Jul 27, 2011·Environmental Toxicology and Pharmacology·Izabela Sadowska-WodaEdyta Bieszczad-Bedrejczuk
Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Fatih DilekAbdurrahim Kocyigit
May 21, 2013·Journal of Ethnopharmacology·Yi-hsuan LinSien-hung Yang
Apr 14, 2009·Annales de dermatologie et de vénéréologie·A Levy-RoyA Dupuy
Mar 30, 2017·Cutaneous and Ocular Toxicology·A MaouiaA Kassab
Jan 18, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·R SpeeckaertN van Geel
Apr 25, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Medha RajappaPampa Ch Toi
Jul 2, 2021·Journal of Traditional and Complementary Medicine·Abdul Mobeen, A Khaleel Ahmad

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