Influence of Dexmedetomidine on the Tourniquet Related Responses in Hypertension Patients Receiving Unilateral Knee Arthroplasty under General Anesthesia

The Journal of Arthroplasty
Yong-Hua LiMou-Li Tian

Abstract

This study aimed to investigate the influence of dexmedetomidine (DEX) on the tourniquet related responses in hypertension patients receiving unilateral knee arthroplasty (UKA) under general anesthesia. Results showed that the incidence of tourniquet induced hypertension (TIH), hemodynamics, MAC and EtSEV in DEX group were significantly lower than those in control group, regardless of hypertension. However, significant differences in TIH, hemodynamics, minimum alveolar concentration (MAC) and end-tidal sevoflurane (EtSEV) were not observed between hypertension patients and non-hypertension patients in both control group and DEX group. Moreover, oxygen index (OI) and respiratory index (RI) remained unchanged after deflation and DEX failed to affect OI and RI within 30 min after deflation, regardless of hypertension. Taken together, DEX may significantly improve the hemodynamics, which is independent of pre-existing hypertension.

References

Mar 1, 1982·British Journal of Anaesthesia·R D Kaufman, L F Walts
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·Constantinos Chrysostomou, Carol G Schmitt
Dec 23, 2009·American Journal of Therapeutics·Joy AlleeJoseph D Tobias
Jan 26, 2013·The Kaohsiung Journal of Medical Sciences·Evrim BostankoluIsil Ozkocak Turan
May 4, 2013·The Kaohsiung Journal of Medical Sciences·Yao LuGordon Tin-Chun Wong

❮ Previous
Next ❯

Citations

May 31, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yonghua LiHongbin Yuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

The Journal of Bone and Joint Surgery. British Volume
O AguG Hamilton
The Journal of Bone and Joint Surgery. British Volume
H Omeroğlu, S Seber
The Journal of Bone and Joint Surgery. British Volume
K S EyresA Abdel-Salam
The Medical Letter on Drugs and Therapeutics
© 2021 Meta ULC. All rights reserved