Influence of diabetes mellitus duration on the efficacy of ischemic preconditioning in a Zucker diabetic fatty rat model

PloS One
Marie Vognstoft HjortbakHans Erik Bøtker

Abstract

Augmented mortality and morbidity following an acute myocardial infarction in patients with diabetes mellitus Type 2 (T2DM) may be caused by increased sensitivity to ischemia reperfusion (IR) injury or altered activation of endogenous cardioprotective pathways modified by T2DM per se or ischemic preconditioning (IPC). We aimed to investigate, whether the duration of T2DM influences sensitivity against IR injury and the efficacy of IPC, and how myocardial glucose oxidation rate was involved. Male Zucker diabetic fatty rats (homozygote (fa/fa)) at ages 6-(prediabetic), 12- (onset diabetes) and 24-weeks of age (late diabetes) and their age-matched non-diabetic controls (heterozygote (fa/+) were subjected to IR injury in the Langendorff model and randomised to IPC stimulus or control. T2DM rats were endogenously protected at onset of diabetes, as infarct size was lower in 12-weeks T2DM animals than in 6- (35±2% vs 53±4%; P = 0.006) and 24-weeks animals (35±2% vs 72±4%; P<0.0001). IPC reduced infarct size in all groups irrespective of the presence of T2DM and its duration (32±3%; 20±2%; 36±4% respectively; (ANOVA P<0.0001). Compared to prediabetic rats, myocardial glucose oxidation rates were reduced during stabilisation and early r...Continue Reading

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Citations

Mar 3, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Hans Erik BøtkerNichlas Riise Jespersen
Feb 24, 2019·Cardiovascular Research·Derek J HausenloyDavid Garcia-Dorado
Aug 17, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Neoma T BoardmanEllen Aasum
Jan 24, 2019·International Journal of Molecular Sciences·Rebekka Vibjerg JensenHans Erik Bøtker
Apr 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anne C van ErpBente Jespersen
Mar 6, 2021·Molecular and Cellular Biochemistry·Pernille Tilma TonnesenNichlas Riise Jespersen
Mar 11, 2021·Basic Research in Cardiology·Thomas Ravn LassenHans Erik Bøtker
May 6, 2021·Canadian Journal of Physiology and Pharmacology·Ekaterina PershinaAlexey Ovechkin

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