PMID: 6408673Jan 1, 1983Paper

Influence of diazepam and methylphenidate on identification of rapidly presented letter strings: diazepam enhances visual masking

Psychopharmacology
H U FischC Menz

Abstract

The effect of diazepam (0, 5, 10 mg) and methylphenidate (0, 5, 10 mg) on the identification of briefly displayed letter strings composing words was investigated. Each letter was presented for 70 ms. The interstimulus interval (ISI) between two successive letters was 10, 100 or 200 ms. The length of the words (WL) was three, five, seven or nine letters. The dependent variable was the number of correctly identified words. As predicted, strong visual masking effects, the strength of which was dependent on ISI and WL, appeared. In the 10 ms condition, diazepam at both doses, but not methylphenidate, further enhanced masking. It is suggested that the results reflect the effect of GABA on masking, and support certain psychological theories about the inhibitory neuronal pathways that are involved in masking. The human peripheral visual system is a promising model for the experimental assessment and integration of pharmacodynamic, neurophysiological and psychological observations.

References

Jan 1, 1979·British Journal of Clinical Pharmacology·J R Wittenborn
Jan 1, 1974·Psychopharmacologia·J A SternJ McClure
Nov 24, 1967·Deutsche medizinische Wochenschrift·K Meier-EwertP Friedenberg
Feb 5, 1982·European Journal of Pharmacology·C W Kamp, W W Morgan
Jan 1, 1981·Psychopharmacology·S J Rothenberg, D Selkoe
Jan 1, 1981·Psychopharmacology·S J Rothenberg, D Selkoe
May 20, 1982·The New England Journal of Medicine·J Kagan
Dec 1, 1981·Perception & Psychophysics·B G Breitmeyer, M E Rudd
Aug 1, 1980·Archives of General Psychiatry·J L RapoportE J Mikkelsen
Jan 1, 1980·Vision Research·P Lennie
Dec 1, 1966·The Journal of Physiology·C Enroth-Cugell, J G Robson

❮ Previous
Next ❯

Citations

Apr 1, 1988·Biological Psychiatry·B D SchwartzD K Winstead
Dec 10, 1984·Brain Research·H R LiebermanR J Wurtman
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G BaktiJ Bircher
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A Branch
Apr 28, 2009·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Christoph FlückigerUlrike Willutzki
Apr 1, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne Giersch, Michael H Herzog
Jan 1, 1985·Annals of the New York Academy of Sciences·H R LiebermanR J Wurtman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.