Influence of diet on experimental toxicity of amphotericin B deoxycholate.

Antimicrobial Agents and Chemotherapy
P ChavanetP Yeni

Abstract

The effects of pre- and postprandial levels of lipids in serum on the experimental in vivo and in vitro toxicities of amphotericin B deoxycholate (AmB-d) were studied. Normal OF1 mice were tested at baseline, after normal feeding, after 3 h of fasting, or after a sequence of feeding and fasting and vice versa. The 50% lethal dose (LD50) of AmB-d was significantly higher in fed mice than in mice which fasted or at baseline (2.38 +/- 0.12 versus 1.53 +/- 0.2 and 1.50 +/- 0.1 mg/kg of body weight, respectively; P < 0.05). When different nutritional regimens were alternated over a short period, the level of in vivo AmB-d toxicity was dictated by the last feeding regimen. Serum triglycerides, but not cholesterol in very-low-density and low-density lipoproteins, correlated significantly (P < 0.01) with the LD50 of AmB. In vitro experiments showed that the addition of human serum reduced AmB-d-induced toxicity against human erythrocytes, but serum drawn after fasting was less protective than postprandial serum. However, neither serum decreased the in vitro activity of AmB-d against Candida albicans. Circular dichroism, a method that enables the amount of free AmB to be measured, showed that both mouse and human total serum lipoprotein...Continue Reading

References

Feb 1, 1978·Antimicrobial Agents and Chemotherapy·A J Atkinson, J E Bennett
Oct 1, 1992·Antimicrobial Agents and Chemotherapy·J BarwiczI Gruda
Nov 1, 1992·Antimicrobial Agents and Chemotherapy·P LegrandJ Bolard
Mar 25, 1992·JAMA : the Journal of the American Medical Association·G R CooperR C Schlant
Dec 16, 1991·Biochemical and Biophysical Research Communications·J BarwiczI Gruda
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·J BrajtburgG Medoff
Aug 15, 1988·Biochemical and Biophysical Research Communications·I GrudaG Medoff
Jul 1, 1988·Analytical Biochemistry·S JullienJ Bolard
Jul 1, 1988·Biochimica Et Biophysica Acta·M C CamusD Lemonnier
Jan 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R A LevyJ Brajtburg
Jun 1, 1984·The Journal of Infectious Diseases·J BrajtburgG Medoff
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y C Ha, P J Barter
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·K M WasanG Lopez-Berestein

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Citations

Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Karen BartlettKishor M Wasan
Oct 20, 2004·Drug Development and Industrial Pharmacy·Verica RisovicKishor M Wasan
Jan 28, 2016·Journal of Medicinal Chemistry·Assaf HalperinItai Benhar
Apr 21, 1998·Journal of Pharmaceutical Sciences·K M Wasan, S M Cassidy
Apr 1, 1996·The Annals of Pharmacotherapy·J D Cleary
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·M LeBrunD Beauchamp

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