PMID: 6411877Sep 1, 1983Paper

Influence of diet on glucose turnover and rates of gluconeogenesis, oxidation and turnover of D-(-)-lactate in the bovine

The Journal of Nutrition
D L HarmonR L Prior

Abstract

D-(-)-Lactate metabolism as influenced by the level of roughage in the diet was examined in eight Hereford heifers (306 kg) fed ad libitum as alfalfa hay diet (R) (2.02 Mcal ME/kg) (ME, metabolizable energy) or a 90% concentrate diet (C) (2.95 Mcal ME/kg) for 18 days. Animals were adjusted to negative pressure hoods (188 liter/minute airflow) and fitted with jugular and urinary catheters. Animals received 32.2 and 71.4 microCi of D-[U-14C]lactate and 435.7 and 233.3 microCi of 2-[3H]glucose for the primer dose and hourly infusion rates, respectively. Blood, expired CO2 and urine samples were taken at 30-minute intervals for 6 hours with CO2 and urine samples taken for an additional 24 and 42 hours, respectively. ME intakes were not different between diets (P greater than 0.05) for the day of infusion. Glucose turnover rates were 143.3 and 154.3 mmol/hour, whereas, D-(-)-lactate turnover was 0.67 and 0.57 mmol/hour for R anc C, respectively. Rates of oxidation and gluconeogenesis were 0.61 and 0.22 mmol/hour for R and 0.55 and 0.16 mmol/hour for C. Recovery of 14C in urine and expired air accounted for 3.73 and 44.3% of the infused dose for R and 2.13 and 43.5% of the infused dose for C. Oxidation was the major route of D-(-)-la...Continue Reading

Citations

Dec 21, 2010·IUBMB Life·Jörg R AschenbachGregory B Penner
Jul 5, 2013·Animal : an International Journal of Animal Bioscience·M Larsen, N B Kristensen
Jul 1, 1997·Journal of Dairy Science·J P Goff, R L Horst
May 1, 1997·Journal of Dairy Science·J E Nocek
Jun 29, 2021·Journal of Dairy Science·L E Hernández-CastellanoM Larsen

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