Influence of diet on the induction of experimental autoimmune thyroid disease

Proceedings of the Society for Experimental Biology and Medicine
S K BhatiaR C Kuppers

Abstract

Immunization of CBA/J mice with thryoglobulin (Tg) emulsified in complete Freund's adjuvant induces experimental thyroiditis (EAT), a well-characterized model of Hashimoto's disease. Recent studies have suggested that dietary factors play a role in the modulation of the immune response and that diet can have a profound effect on the induction of autoimmune diseases. In this study, we examined the influence of diet on autoimmune thyroiditis in mice. EAT was induced in mice fed ad libitum one of the three diets, a standard maintenance chow (Agway H1000), Purina 5020 Breeding Chow, and Purina 5010 Autoclavable (unautoclaved) Diet. Tg-immunized mice fed the Agway 1000 diet were found to be resistant to the development of autoimmune thyroid disease, with only 4 out of 25 mice developing mild thyroiditis. In contrast, 16 out of 25 mice fed the Purina 5010 diet developed moderate to severe thyroiditis. Mice fed the 5020 diet were partly susceptible: 7 out of 25 developed a mild to moderate thyroiditis. Histologic examination of thyroid glands of diseased mice fed the 5010 and 5020 diets showed marked lymphocytic infiltration with destruction of follicles, compared with mice fed the Agway diet, the latter showing only mild infiltration...Continue Reading

Citations

Oct 27, 1998·Journal of Neuroscience Research·F MorT Unger
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Stephen B. Pruett
Sep 29, 2018·Journal of the American College of Nutrition·Dean KaličaninVesna Boraska Perica
Oct 20, 2001·Journal of Applied Physiology·M D Lockshin
Jul 2, 2020·Scientific Reports·Dean KaličaninVesna Boraska Perica

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