PMID: 8946559Nov 1, 1996Paper

Influence of dietary folic acid on the developmental toxicity of methanol and the frequency of chromosomal breakage in the CD-1 mouse

Reproductive Toxicology
S S FuC L Keen

Abstract

The proposed increased use of methanol (MeOH)-based fuels raises the concern for an increased risk for MeOH toxicity. MeOH, which is detoxified in part via a folate-dependent pathway, is known to be teratogenic in rodents. Previous observations have implicated maternal folate status as a critical modulator for the developmental toxicity of MeOH. The current study extends these findings, examining the effect of maternal dietary folate intake on fetal folate stores, as well as identifying a possible marker for the prediction of the developmental toxicity of MeOH. Virgin female CD-1 mice were assigned to diets containing either 400 (marginal) or 1200 (control) nmol folic acid (FA)/kg, and and 1% succinylsulfathiazole for 5 weeks prior to mating and throughout breeding and gestation. From gestation day (GD) 6 through 10 dams were given by gavage deionized, distilled water (dH2O) or MeOH at 2.5 g/kg body weight, twice daily. On GD 18, mice were weighed and killed and the liver, kidneys, and gravid uteri removed and weighed. Implantation sites, live and dead fetuses, and resorptions were counted; fetuses were weighed individually and examined for cleft palate and exencephaly. The marginal FA dietary treatment resulted in low maternal...Continue Reading

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Citations

Apr 15, 2004·Reproductive Toxicology·Michael ShelbyUNKNOWN NTP-CERHR Expert Panel
Nov 24, 1999·Reproductive Toxicology·I ChahoudA S Faqi
Jul 20, 2002·Neurotoxicology and Teratology·Moammir Hasan AzizPrahlad Kishore Seth
Nov 28, 2012·BMC Pediatrics·George L WehbyJeffrey C Murray
Mar 25, 2010·Oral Diseases·G L Wehby, J C Murray
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Jun 12, 2009·Critical Reviews in Toxicology·George Cruzan
Jun 7, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jillian Theobald, Christopher Lim

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