PMID: 11906568Mar 22, 2002Paper

Influence of dietary phosphorus deficiency with or without addition of fumaric acid to a diet in pigs on bone parameters

Journal of Animal Physiology and Animal Nutrition
A LiesegangM Wanner

Abstract

The purpose of this study was to examine if substantial bone loss occurs in weaned pigs by feeding a phosphorus-deficient diet with or without fumaric acid. Eighteen weaned pigs were used. The animals were assigned to three groups: group C (control; 0.65% P on DM basis), group LP (low phosphorus; 0.37% P on DM basis) and group LPF (low phosphorus plus fumaric acid; 0.35% P on DM basis plus 2% fumaric acid). These three diets were fed to the groups for a period of four weeks after a two-week adaptation period. Blood samples were collected once a week. Carboxyterminal telopeptide of type I collagen (ICTP) in serum was used as a bone resorption marker. Osteocalcin (OC) and bone-specific alkaline phosphatase (bAP) were used as bone formation markers. Bone mineral density (BMD) and content (BMC) were determined by peripheral quantitative computer tomography. BAP activities significantly increased (24%) in group LPF, and at the last sampling day group LPF had significantly increased activities in comparison to group C. In contrast, ICTP concentrations significantly increased with time in group LP and LPF, and at the last sampling day group LPF had significantly increased activities in comparison to group C. BMD and BMC in femur and t...Continue Reading

Citations

Apr 9, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Jennifer LakeGrant W Vandenberg
May 29, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shozo H Sugiura, Ronaldo P Ferraris
Jul 6, 2018·Journal of Animal Physiology and Animal Nutrition·Sarah K DuffyJohn V O'Doherty
Jan 11, 2019·Journal of the Science of Food and Agriculture·Kristina U SørensenHanne D Poulsen
Mar 18, 2020·Journal of Animal Physiology and Animal Nutrition·Christian GerlingerPetra Wolf
Jun 25, 2013·Journal of the Science of Food and Agriculture·Jeannine NeethlingTrevor J Britz
Apr 1, 2017·Translational Animal Science·C F HuangC H Lai

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