Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain.

The American Journal of Clinical Nutrition
Eva FisherHeiner Boeing

Abstract

Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition. Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain become...Continue Reading

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Jun 8, 2013·The Journal of Physiological Sciences : JPS·Ewa ZiemannRadosław Laskowski
Dec 2, 2015·The British Journal of Nutrition·Katherine M LivingstoneUNKNOWN Food4Me study
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Sep 11, 2019·The Journal of Nutrition·Mercedes Sotos-PrietoJosiemer Mattei
Jul 22, 2018·Molecular Biology Reports·Sukma OktavianthiSafarina G Malik

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