Influence of dietary quercetin on glutathione redox status in mice

Journal of Agricultural and Food Chemistry
Katherine J MeyersAlyson E Mitchell

Abstract

Flavonoids such as quercetin have been shown to serve as a protective defense against oxidative damage in vivo. However, the bioavailability of quercetin depends on the food source and type of glycosidic moiety linked to the molecule. In this study, mice were fed 1 mg/day quercetin in the form of quercetin aglycone, rutin, apple, or onion, and reduced glutathione (GSH), oxidized glutathione (GSSG), and protein-GSH mixed disulfides were determined to investigate the influence of dietary quercetin on the GSH redox status in metabolically active tissues, mitochondria, and plasma of mice. All quercetin treatment groups produced increases in the GSH:GSSG ratio and decreases in mixed disulfide levels in hepatic tissue. Cardiac tissue did not change in response to dietary quercetin; however, cardiac mitochondria demonstrated a reduction in the GSH:GSSG ratio and an increase in protein mixed disulfide levels. No significant changes were observed in the plasma GSH:GSSG ratio, but mixed disulfide levels were decreased for all of the diets. The changes in plasma redox status did not parallel the changes in the tissues. Onion fed mice demonstrated the greatest increases in GSH:GSSG ratios and the greatest decreases in protein mixed disulfi...Continue Reading

Citations

Jun 2, 2011·Journal of Agricultural and Food Chemistry·John W FinleyXin Gen Lei
Jul 10, 2012·Doklady. Biochemistry and Biophysics·E B BurlakovaN I Krikunova
Feb 3, 2011·Archives of Toxicology·Gustavo Rafael Mazzaron BarcelosFernando Barbosa
Mar 20, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ewa ChlebdaAdam Szelag
Jan 7, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana SarićTatjana Marotti
Aug 29, 2013·Oxidative Medicine and Cellular Longevity·Marco MalagutiSilvana Hrelia
Dec 1, 2017·Journal of Food Science and Technology·Yolanda Salinas MorenoIvone Alemán de la Torre
Jan 29, 2011·Izvestiia Akademii nauk. Seriia biologicheskaia·E B BurlakovaA N Goloshchapov
Apr 5, 2021·Neuroscience Letters·Orhan Sumbul, Hatice Aygun

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