PMID: 9179830May 1, 1997Paper

Influence of dietary restriction on ionotropic glutamate receptors during aging in C57B1 mice

Mechanisms of Ageing and Development
Kathy Ruth Magnusson

Abstract

The present study was designed to determine whether the memory sparing effects of dietary restriction during aging could be through an effect on ionotropic glutamate receptors. Quantitative autoradiography was performed on 3, 10, and 26 month old mice to examine the density changes of NMDA, AMPA and kainate binding sites in aging animals. Spatial memory performance was also tested in these mice with the use of the Morris water maze. The 10 and 26 month olds were either ad libitum-fed or diet-restricted (60% of ad libitum-fed calories). Ad libitum-fed, 26 month old mice had significant decreases in NMDA-displaceable [3H]glutamate in all ten cortical, two out of seven hippocampal, and two out of four subcortical regions, as compared to 3 month olds. Diet-restricted, 26 month old mice only differed significantly from young in three cortical and two subcortical regions. The aged ad libitum-fed mice exhibited significantly poorer performance in the spatial memory task than all other groups. The diet-restricted 26 month olds only performed significantly worse than 3 month olds and diet-restricted 10 month olds. These results suggest that some of the memory sparing effects of dietary restriction on aged animals may be due to an influe...Continue Reading

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Citations

Nov 18, 1998·Mechanisms of Ageing and Development·K R Magnusson
Oct 24, 2002·Neurobiology of Aging·N V Patel, C E Finch
Apr 26, 2003·Neurobiology of Aging·Karyn M Frick, Stephanie M Fernandez
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Sep 20, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·K R MagnussonC Dunlop
Apr 5, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathy Ruth MagnussonPeter R Patrylo
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ruolan LiuMichel Baudry
Dec 23, 2003·The European Journal of Neuroscience·Michelle M Nicolle, Mark G Baxter
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Geoffrey G MurphyAlcino J Silva
Dec 17, 2009·Neurobiology of Aging·C FouquetL Rondi-Reig
Dec 15, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ogechi IgweSerdar M Dursun

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