Influence of dietary selenium on the disposition of arsenate in the female B6C3F1 mouse

Journal of Toxicology and Environmental Health
E M KenyonO A Levander

Abstract

Interactions between arsenic (As) and selenium (Se) at the metabolic level are multifaceted and complex. These interactions are of practical significance because populations in various parts of the world are simultaneously exposed to inorganic As in drinking water and Se mainly in the diet at varying levels. The primary goal of this study was to investigate whether differing dietary Se status would alter the profile of urinary metabolites or their time course for elimination after exposure to arsenate [As(V)]. Weanling female B6C3F1 mice were maintained for 28 d on either a control diet of powdered rodent meal sufficient in Se (A, 0.2 ppm) or Torula yeast-based (TYB) diets deficient (B, 0.02 ppm Se), sufficient (C, 0.2 ppm Se), or excessive (D, 2.0 ppm Se) in Se; mice then received by oral gavage 5 mg (As)/kg as sodium [73As] arsenate. The time course for elimination of total arsenic and metabolites in urine was measured over a 48-h period, and total arsenic was determined in feces and tissues at 48 h. Mice on the Se excess diet excreted a significantly higher percentage of urinary As as inorganic As, with a significantly decreased ratio of organic to inorganic As compared to Se-sufficient mice, suggesting that As methylation w...Continue Reading

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Citations

Jun 15, 2013·Environmental Science and Pollution Research International·Jack C NgRavi Naidu
Jun 19, 2004·International Journal of Environmental Health Research·Abul Hasnat MiltonWayne Smith
Dec 12, 2003·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryHarvey J Clewell
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Feb 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·E M KenyonM F Hughes

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