Influence of different energy densities of laser phototherapy on oral wound healing

Journal of Biomedical Optics
Vivian Petersen WagnerManoela D Martins

Abstract

The aim of the present prospective study was to evaluate the impact of laser phototherapy (LPT) on the healing of oral ulcers. Different power densities were used on oral wounds in Wistar rats (n=72) randomly divided into three groups: control (0 J/cm2), 4 J/cm2 laser, and 20 J/cm2 laser. Ulcers (3 mm in diameter) were made on the dorsum of the tongue with a punch. Irradiation with an indium-gallium-aluminum-phosphide laser (660 nm; output power: 40 mW; spot size: 0.04 cm2) was performed once a day in close contact with the ulcer for 14 consecutive days. A statistically significant acceleration in healing time was found with wounds treated with 4 J/cm2 LPT. Moreover, striking differences were found in the ulcer area, healing percentage, degree of reepithelialization, and collagen deposition. The most significant changes occurred after 5 days of irradiation. Based on the conditions employed in the present study, LPT is capable of accelerating the oral mucosa wound-healing process. Moreover, faster and more organized reepithelialization and tissue healing of the oral mucosa were achieved with an energy density of 4 J/cm2 in comparison to 20 J/cm2.

Associated Clinical Trials

Citations

Feb 13, 2016·Lasers in Medical Science·Vivian Petersen WagnerManoela Domingues Martins
Sep 19, 2015·International Journal of Oral and Maxillofacial Surgery·M M A RomãoC A Lascala
Apr 17, 2015·TheScientificWorldJournal·Fernando Alves ValeKaren Muller Ramalho
Mar 13, 2017·Lasers in Medical Science·Fernanda Gonçalves BassoCarlos Alberto de Souza Costa
Mar 2, 2019·Lasers in Medical Science·Amanda de Farias GabrielManoela Domingues Martins
Dec 11, 2019·Lasers in Surgery and Medicine·Hyoung Shin LeeHyun Wook Kang
Sep 25, 2017·Photochemistry and Photobiology·Fernanda G BassoCarlos Alberto de Souza Costa
Feb 18, 2014·Journal of Biomedical Optics·Ana Carolina Amorim PellicioliRogerio M Castilho
Jun 16, 2017·BMC Complementary and Alternative Medicine·Francisco Bruno TeixeiraRafael Rodrigues Lima
Jun 3, 2014·Journal of Biomedical Optics·Caroline Siviero DillenburgManoela Domingues Martins
Aug 2, 2017·Photochemistry and Photobiology·Heng ZhangTaihao Li
Mar 28, 2017·Lasers in Medical Science·Valerie G A SuterMichael M Bornstein
Oct 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Chuan-Tsung SuJih-Huah Wu
Jan 1, 2016·Journal of Biomedical Optics·Marina CurraManoela Domingues Martins
Jul 31, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Rosa AbellánJuan Carlos Palma
Jul 16, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chris K DanileviczManoela D Martins

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