PMID: 8942332Oct 1, 1996Paper

Influence of different volume therapy regimens on regulators of the circulation in the critically ill

British Journal of Anaesthesia
J BoldtG Hempelmann

Abstract

Various vasoactive substances are involved in the regulation of the macro- and microcirculation. We have investigated if these regulators change during long-term volume therapy with human albumin (HA) or hydroxyethylstarch solution (HES) in trauma and sepsis patients. To maintain pulmonary capillary wedge pressure (PCWP) at 10-15 mm Hg, either 20% HA (HA-trauma, n = 14; HA-sepsis, n = 14) or 10% low-molecular weight HES solution (HES-trauma, n = 14; HES-sepsis, n = 14) were infused for 5 days, otherwise patient management did not differ between the two groups (trauma/sepsis). Mean arterial pressure (MAP), heart rate (HR), PCWP and cardiac index (CI) were monitored in all patients. Liver function was assessed using the monoethylglycinexylidide (MEGX) test, and gastric intramucosal pH (pHi) was monitored by tonometry to assess splanchnic perfusion. Plasma concentrations of vasopressin, endothelin-1, adrenaline, noradrenaline, atrial natriuretic peptide and 6-keto-prostaglandin F1 alpha were measured from arterial blood samples. All measurements were carried out on the day of admission to the intensive care unit (trauma patients) or on diagnosis of sepsis, and daily over the next 5 days at 12:00. MAP, HR and PCWP did not differ be...Continue Reading

Citations

May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Joachim Boldt
Oct 27, 2004·Der Anaesthesist·C WunderO Eichelbrönner
Aug 19, 2006·The Journal of Trauma·Jennifer M WattersMartin A Schreiber
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Frédérique SchortgenGreg S Martin
Mar 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobMarkus Rehm
Aug 11, 2007·Expert Opinion on Drug Safety·Byron ChalidisPeter V Giannoudis
Oct 20, 2001·Disease-a-month : DM·P E Marik, J Varon
Sep 19, 2006·Journal of Clinical Epidemiology·John P A IoannidisElias Zintzaras
Nov 7, 2000·British Journal of Anaesthesia·J P NicholsonG R Park
Dec 1, 1998·Journal of Clinical Pharmacy and Therapeutics·S NatschY A Hekster
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Ilse VanhorebeekGreet Van den Berghe
Aug 2, 2000·Critical Care Medicine·P E Marik, J Iglesias
Jan 31, 2006·Journal of the Royal Army Medical Corps·R C C Thompson
Apr 11, 2001·Therapeutic Drug Monitoring·M Oellerich, V W Armstrong
May 15, 2020·Intensive Care Medicine·UNKNOWN Editorial Office of Intensive Care Medicine
Mar 4, 2008·The International Journal of Artificial Organs·J A KellumP M Palevsky
Dec 12, 2001·Critical Care : the Official Journal of the Critical Care Forum·C J FernandesE Knobel
Dec 12, 2018·The Cochrane Database of Systematic Reviews·Danyang LiYi Xia

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