PMID: 3383989Jan 1, 1988Paper

Influence of digestive secretions and food on intestinal absorption of nicardipine

European Journal of Clinical Pharmacology
J C DelchierD Lavene

Abstract

The role of digestive absorption in the pharmacokinetics of nicardipine has been studied by the perfusion technique. Nicardipine (40 mg) was perfused in six healthy subjects at 5 ml/min for 2 h either in isotonic saline with (Experiment A) or without (B) an occlusive balloon isolating the test segment from digestive secretions, or in a nutrient solution (Experiment C). In Experiments A and B, 100% of nicardipine was absorbed from the jejunal lumen in a 25 cm test segment and in Experiment C it was slightly lower (94%). There was no relationship between the absorption of nicardipine and water movement or bile salt concentration in the jejunum. Nicardipine was already present in the first plasma sample taken after 15 min and the peak level was found at the end of the perfusion. The areas under the curves differed widely between subjects, because of interindividual variation in the first pass effect, but they were similar in Experiments A, B and C. The experimental data showed a good fit to a mode involving a two-phase absorption process. The first phase was associated with intestinal perfusion (zero order process) and the second with passage across the intestinal wall (1st order process). In three further healthy subjects, nicard...Continue Reading

Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·M GuerretD Lavene
Jun 16, 2004·Clinical and Experimental Hypertension : CHE·Fiorenzo MigniniFrancesco Amenta
Dec 1, 1994·Biopharmaceutics & Drug Disposition·T Gramatté

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