Influence of dimethylfumarate on experimental HSV-1 necrotizing keratitis

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Arnd HeiligenhausDirk Bauer

Abstract

This study was performed to investigate the influence of fumaric acid esters on the course of herpes stromal keratitis (HSK). The corneas of BALB/c mice were inoculated with 105 plaque-forming units of herpes simplex virus 1 (HSV-1, KOS strain). Groups of mice were treated intraperitoneally with phosphate buffered saline (PBS) (control mice), or with dimethylfumarate (DMF) at 15 mg/kg of body weight dissolved in PBS daily for 28 days pre-infection and for 14 days post-infection. The course of HSV-1 keratitis was studied clinically. Corneal sections were examined for inflammatory cell infiltration. The numbers of CD3, GR-1, CD11b and F4/80-expressing cells infiltrating the corneas were analyzed by immunohistochemistry. On day 14 after HSV infection, 72% of the mice in the control group had severe HSK. The development of HSK was reduced by DMF treatment in the DMF group (22%) (P=0.004). The total number of inflammatory cells and infiltration of polymorphonuclear-neutrophils (PMNs) were reduced in the corneas of DMF-treated mice. Compared to the PBS-treated mice, numbers of CD3, CD11b, GR-1 and F4/80-positive cells were reduced in the DMF group of mice. The course of experimental herpes stromal keratitis can be improved with syste...Continue Reading

Citations

Sep 28, 2005·Archives of Dermatological Research·Kejian Zhu, Ulrich Mrowietz
Aug 27, 2013·Critical Reviews in Immunology·Alexander J Gill, Dennis L Kolson

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