Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers

The Journal of Pharmacy and Pharmacology
Jelena ParojcićD Jovanović

Abstract

The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution meth...Continue Reading

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Citations

Apr 12, 2008·Pharmaceutical Research·Ekarat JantratidJennifer B Dressman
Jan 25, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·María V Ramírez-RigoRuben H Manzo
Jul 3, 2015·Drug Development and Industrial Pharmacy·Ignacio González-GarcíaMarival Bermejo
Jul 17, 2007·Journal of Pharmaceutical Sciences·Ana Ruiz-GarciaVicente G Casabo
May 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N FotakiC Reppas
Feb 6, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T NabaisL Cartilier
Dec 19, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Feng ChaiHartmut F Hildebrand
Jul 11, 2006·International Journal of Pharmaceutics·Ganesh S BommareddySteven H Neau
Sep 17, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rafael Barreiro-IglesiasAngel Concheiro
Jul 11, 2012·Pharmaceutical Development and Technology·Safwan Abdel RahimNizar Al-Zoubi
Oct 14, 2006·Therapeutic Drug Monitoring·Johannes KornhuberIngolf Meineke
Jan 22, 2010·CNS Drugs·Richard C SheltonSara A Corya

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