Influence of DNA ploidy and adjuvant treatment on progression and survival in patients with pathologic stage T3 (PT3) prostate cancer after radical retropubic prostatectomy

Urology
C A HawkinsH Zincke

Abstract

To determine whether adjuvant treatment (AT: hormonal or radiation) affects outcome in pathologic Stage T3 (pT3) prostate cancer when analyzed according to DNA ploidy. The predictive value of nuclear DNA ploidy and AT on clinical and prostate-specific antigen (PSA) progression and on overall and cause-specific survival after radical retropubic prostatectomy was assessed in 894 patients with pT3 prostate cancer. Mean follow-up was 6.7 years (range, 0.3 to 20). Mean age was 66 years (range, 39 to 79). Six hundred sixty patients (74%) had no immediate AT, 131 (15%) had early adjuvant radiotherapy (ART), and 103 (12%) had early adjuvant orchiectomy (AHT). DNA diploid tumors were found in 445 patients (52%), tetraploid tumors in 346 (41%), and aneuploid tumors in 59 (7%). DNA ploidy was a significant (P < 0.05) prognostic indicator for clinical systemic progression-free survival. With PSA progression (more than 0.2 ng/mL) as an endpoint, ploidy was an even more powerful predictor for outcome (P = 0.004). Use of early AHT or ART was associated with decreased overall clinical progression for diploid and nondiploid tumors (P < 0.001 and P < 0.001, respectively). With respect to PSA progression, ART and AHT were equally effective and su...Continue Reading

References

Aug 1, 1989·Mayo Clinic Proceedings·O NativM M Lieber
Sep 15, 1969·JAMA : the Journal of the American Medical Association·D C Utz, G M Farrow
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove

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Citations

Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Carlos VargasAlvaro A Martinez
Oct 10, 2001·The Urologic Clinics of North America·S E Schild, T M Pisansky
May 15, 2002·Critical Reviews in Oncology/hematology·Ulka Vaishampayan, Maha Hussain
Mar 11, 2010·Current Opinion in Urology·Robert L Grubb, Adam S Kibel
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A PollackW U Shipley
Nov 6, 2010·BJU International·David S YeeJames A Eastham
Nov 11, 2005·The Journal of Urology·Liang ChengMichael O Koch
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·Jonathan I EpsteinRodolfo Montironi
Jul 13, 2005·Mayo Clinic Proceedings·Thomas M Pisansky

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