PMID: 7992365Dec 15, 1994Paper

Influence of donor and histocompatibility factors on corneal graft outcome

A VailW J Armitage


The Corneal Transplant Follow-up Study has followed 2311 penetrating keratoplasties for up to 450 days after transplant. A total of 207 failures were observed, including 65 classical rejections and 35 endothelial decompensations. At 12 months, graft survival was 89%, and survival free from rejection was 87%. For surviving grafts, risk of failure reduced from 4.8% in the first 75 days and stabilized after 5 months at 1.2% in each 75-day interval. Risk of rejection initially followed a similar pattern, but then increased after 12 months. Multifactorial analyses accounted for differences in recipient characteristics and interrelationships of donor factors. Donor age, sex, cause of death, and method of corneal storage were not found to influence significantly either time to graft failure or time to first rejection. Grafts in prospectively tissue-typed donor-recipient pairs were generally considered before surgery to be at increased risk of either graft failure or rejection. With due allowance, increasing risk of rejection was associated with increasing numbers of mismatches at HLA-A and HLA-B broad antigens. The opposite was true at HLA-DR broad antigens, where increased risk of rejection was observed with no mismatches.


May 12, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S C BeutelspacherM O McClure
Sep 25, 2002·Transplantation Proceedings·T BredehornF Wilhelm
Jan 7, 2009·International Ophthalmology Clinics·Helene Lam, M Reza Dana
Apr 19, 2005·The British Journal of Ophthalmology·K A WilliamsD J Coster
Aug 1, 1996·The British Journal of Ophthalmology·M G AyoubiD L Easty
Aug 1, 1997·The British Journal of Ophthalmology·A VailW J Armitage
Jun 26, 1998·The British Journal of Ophthalmology·V M BorderieL Laroche
Aug 6, 1999·The British Journal of Ophthalmology·V M BorderieL Laroche
Sep 30, 2000·Clinical and Experimental Immunology·S A RaynerD F Larkin
Mar 13, 2003·Immunology and Cell Biology·Michael A ThielKeryn A Williams
Jun 24, 2010·American Journal of Ophthalmology·Marc-Antoine Chatel, Daniel F P Larkin
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J Saravana GaneshUNKNOWN Steering Group of the UK Cardiothoracic Transplant Audit
Jan 7, 2006·Acta Ophthalmologica Scandinavica·Jørgen Krohn, Gunnar Høvding
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J T George, D F P Larkin
Dec 26, 2016·Survey of Ophthalmology·Antonio Di ZazzoReza Dana
Mar 9, 2004·Eye·W J Armitage
Nov 7, 2007·Transplantation·Keryn A Williams, Douglas J Coster
Nov 25, 2003·Eye·D J Coster, K A Williams

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