Influence of dorsolateral prefrontal cortex and ventral striatum on risk avoidance in addiction: a mediation analysis

Drug and Alcohol Dependence
Dorothy J YamamotoJody Tanabe

Abstract

Alterations in frontal and striatal function are hypothesized to underlie risky decision making in drug users, but how these regions interact to affect behavior is incompletely understood. We used mediation analysis to investigate how prefrontal cortex and ventral striatum together influence risk avoidance in abstinent drug users. Thirty-seven abstinent substance-dependent individuals (SDI) and 43 controls underwent fMRI while performing a decision-making task involving risk and reward. Analyses of a priori regions-of-interest tested whether activity in dorsolateral prefrontal cortex (DLPFC) and ventral striatum (VST) explained group differences in risk avoidance. Whole-brain analysis was conducted to identify brain regions influencing the negative VST-risk avoidance relationship. Right DLPFC (RDLPFC) positively mediated the group-risk avoidance relationship (p < 0.05); RDLPFC activity was higher in SDI and predicted higher risk avoidance across groups, controlling for SDI vs. Conversely, VST activity negatively influenced risk avoidance (p < 0.05); it was higher in SDI, and predicted lower risk avoidance. Whole-brain analysis revealed that, across group, RDLPFC and left temporal-parietal junction positively (p ≤ 0.001) while r...Continue Reading

References

Jul 1, 1989·British Journal of Addiction·L B CottlerJ E Helzer
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O MawlawiM Laruelle
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin P PaulusMarc A Schuckit
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Monique ErnstEdythe D London
Aug 26, 2004·Neuropsychologia·Monique ErnstDaniel S Pine
Oct 16, 2004·Science·Samuel M McClureJonathan D Cohen
Oct 16, 2004·Neuroreport·Scott C MatthewsMartin P Paulus
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
Mar 24, 2006·The European Journal of Neuroscience·Giuseppe BlasiVenkata S Mattay
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daria KnochPeter Brugger
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowChristopher Wong
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmad R HaririStephen B Manuck
Jan 27, 2007·Science·Sabrina M TomRussell A Poldrack
Jun 30, 2007·Cognitive, Affective & Behavioral Neuroscience·Derek Evan NeeJohn Jonides
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shirley FecteauAlvaro Pascual-Leone
Sep 27, 2008·Neuron·Tor D WagerKevin N Ochsner
Nov 29, 2008·Behavioral Sciences & the Law·Sara L DolanPeter E Nathan
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seung-Lark LimLuiz Pessoa
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter N C MohrHauke R Heekeren
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soyoung Q ParkAndreas Heinz
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hedy KoberKevin N Ochsner
Jun 28, 2011·Nature Methods·Tal YarkoniTor D Wager
Nov 15, 2011·Drug and Alcohol Dependence·Laetitia L ThompsonJody Tanabe

❮ Previous
Next ❯

Citations

May 18, 2020·Psychiatry and Clinical Neurosciences·Ali KhaleghiMohammad Reza Mohammadi
May 8, 2018·Annals of Nuclear Medicine·Julia SauerbeckTakamichi Murakami
May 31, 2019·Frontiers in Psychology·Xuejun JinXiaolan Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.