Abstract
The impact of the dose intensity administered in consolidation in Latin America is unknown. This study aimed to evaluate the relative dose intensity (RDI) in consolidation and its impact in overall survival. A retrospective study of 86 patients with AML who were diagnosed between 2010 and 2016 with a 2-year follow-up in a fourth-level Colombian hospital was carried out. Clinical characteristics were reported, Kaplan-Meier was used for estimating the overall survival, and Cox regression was used for multivariate analysis. The median overall survival (OS) was 20.83 months, and the median event-free survival (EFS) was 16.83 months. 64.3% of the patients achieved remission after the 7 + 3 chemotherapy induction treatment. Patients under 30 years of age, with white blood cell counts less than 100.000 cells/mm3 who responded to induction treatment had a better OS. Additionally, patients receiving an RDI greater than 0.75 of the planned consolidation dose had better survival. The prognostic variables with impact in the OS were the leukocyte count in peripheral blood at diagnosis, the RDI in consolidation treatment with HIDAC and the response obtained after induction. This retrospective study allowed us to know the epidemiology of AML ...Continue Reading
References
Mar 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M F N RegoI Lorand-Metze
Mar 11, 2004·Blood Reviews·Krzysztof MrózekClara D Bloomfield
Sep 13, 2006·Leukemia & Lymphoma·Evandro M FagundesMarcos B Viana
Nov 21, 2007·Haematologica·Rafael Henriques JácomoEduardo M Rego
Aug 20, 2009·Journal of Experimental & Clinical Cancer Research : CR·Yoshiki TeradaMasayuki Hino
Jun 2, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Hiroki YamaguchiKoiti Inokuchi
Jul 14, 2012·International Journal of Hematology·Eytan M Stein, Martin S Tallman
Aug 11, 2012·Blood·Ursula CreutzigUNKNOWN AML Committee of the International BFM Study Group
May 1, 2013·The Lancet Oncology·Paul E GossGustavo Azenha
Feb 2, 2015·Revista brasileira de hematologia e hemoterapia·Sergio Lunardon PadilhaNatália Ramos Domino
Mar 27, 2015·Pediatric Blood & Cancer·Amaranto SuarezAlejandro Gutierrez
Sep 1, 2015·Blood·Aleide S LimaMarcos A Bezerra
Dec 4, 2015·Revista médica de Chile·Mónica FuentesPablo Ramírez
Apr 14, 2016·Blood·Daniel A ArberJames W Vardiman
Nov 30, 2016·Blood·Hartmut DöhnerClara D Bloomfield
Aug 5, 2017·Leukemia Research·Mariana Tereza de Lira BenicioEduardo M Rego
Aug 27, 2017·Scientific Reports·Di WuSize Chen
Feb 6, 2018·Lancet·Claudia AllemaniUNKNOWN CONCORD Working Group
Aug 23, 2019·PloS One·Alexander Leonardo Silva-JuniorAllyson Guimarães Costa