Influence of drug loading and type of ointment base on the in vitro performance of acyclovir ophthalmic ointment

International Journal of Pharmaceutics
Manar Al-GhabeishMansoor A Khan

Abstract

The availability of in vitro performance tests such as in vitro drug release testing (IVRT) and in vitro permeation testing (IVPT) are critical to comprehensively assure consistent delivery of the active component(s) from semisolid ophthalmic drug products. The objective was to study the impact of drug loading and type of ointment base on the in vitro performance (IVRT and IVPT) of ophthalmic ointments using acyclovir as a model drug candidate. The in vitro drug release for the ointments was evaluated using a modified USP apparatus 2 with Enhancer cells. The transcorneal permeation was carried out using rabbit cornea on modified vertical Franz cells. The drug retention in cornea (DRC) was also determined at the end of transcorneal drug permeation study. The in vitro drug release, transcorneal drug permeation as well as DRC exhibited a proportional increase with increasing drug loading in the ointment. On comparing the in vitro drug release profile with transcorneal permeation profile, it appears that drug release from the ointment is controlling acyclovir transport through the cornea. Furthermore, enhanced in vitro transcorneal permeation relative to the in vitro drug release underscores the importance of the interplay between ...Continue Reading

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Citations

Apr 23, 2016·Journal of Pharmaceutical Sciences·Fernando Alvarez-RiveraCarmen Alvarez-Lorenzo
Jan 19, 2018·Pharmaceutics·Marion DubaldHatem Fessi
Nov 8, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Panita SuwannoiChristel C Müller-Goymann
Jan 30, 2020·Biomaterials Science·Angela Varela-GarciaCarmen Alvarez-Lorenzo
Sep 10, 2020·Polymers·Angela Varela-GarciaCarmen Alvarez-Lorenzo
Oct 10, 2020·Assay and Drug Development Technologies·Madhur KulkarniAditya Marfatiya
Oct 11, 2020·Pharmaceutical Research·Margarida MirandaCarla Vitorino
Nov 21, 2020·Pharmaceutical Research·Maxime Le MerdyMichael B Bolger
Jun 3, 2021·Pharmaceutics·Nadia ToffolettoAna Paula Serro

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