PMID: 11931490Apr 5, 2002Paper

Influence of early drainage of intraperitoneal phospholipids on efficacy of adhesion prevention

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Stefan A MüllerVolker Schumpelick

Abstract

Postoperative peritoneal adhesions impose a long-term risk of morbidity and mortality. Adjunctive means are needed to prevent these complications. In previous studies we could demonstrate the efficacy and safety of intraperitoneally applied phospholipids with regard to adhesion prevention and wound healing, respectively. The assumption is that phospholipids rapidly adhere to the peritoneal surface and to the mesothelial lesions. This study was designed to evaluate the influence of early drainage of the administered fluid volume on the control of adhesion formation. Forty chinchilla rabbits underwent median laparotomy and standardized abrasion of circumscript areas of the ventral abdominal wall, the cecum, and the ileum. The animals randomly received either 75 mg/kg body weight of phospholipids in a volume of 5.0 mL/kg body weight (n = 20) or the same volume of Ringer's lactate solution (n = 20) prior to closing the laparotomy wounds. In 50% of the rabbits with either medication, 80% of the volume was recovered after 30 min before final closure of the abdominal wall ("drainage"). In the remaining animals the intraabdominal fluid load was not evacuated ("no drainage"). At day 10 after surgery all rabbits were sacrificed for evalu...Continue Reading

Citations

Oct 8, 2005·Scandinavian Journal of Gastroenterology·László NehézRoland Andersson
Aug 17, 2004·International Journal of Colorectal Disease·Marc JansenVolker Schumpelick
Aug 30, 2006·Scandinavian Journal of Gastroenterology·László NehézRoland Andersson
Mar 18, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·T K RajabC W Wallwiener
Dec 29, 2009·The Journal of Surgical Research·Brian C Ward, Alyssa Panitch

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